CARS & SRS with picoEmerald

CARS & SRS with picoEmerald

Stimulated Raman Scattering & Coherent anti-Stokes Raman Scattering

More general information about the tuneable picosecond laser picoEmerald can be found here.



Stimulated Raman Scattering (SRS)

Stimulated Raman Scattering (SRS) microscopy for non-invasive label-free imaging is facilitated via the picoEmerald system. SRS microscopy provides almost background-free imaging contrast. It allows simple spectroscopic identification of the samples’ fingerprint region based on Raman spectra databases. Switching over to SRS microscopy is relatively straightforward for researchers who already have CARS experience.

Coherent Anti-Stokes Raman Spectroscopy (CARS)

CARS Coherent anti-Stokes Raman Spectroscopy (as well as Stimulated Raman Scattering) create high imaging contrast without labeling. The technology involves two laser beams. CARS is sensitive to the vibrational modes of samples and visualizes the vibrational contrast of molecules. The samples, even living objects, remain almost unaffected.


SRS Microscopy and CARS Spectroscopy with a Tunable ps Two-Color Laser


CARS & SRS in a Single-box

SRS Stimulated Raman Scattering microscopy and CARS Coherent Anti-Stokes Raman Spectroscopy have migrated from physics labs to life-science labs, so APE has responded with an easy-to-use and truly hands-off SRS and CARS light source: picoEmerald. In a single-box, picoEmerald provides fully automated temporal- and spatial-overlapping ultra-short pulse trains: 1032 nm from the laser oscillator, plus the OPO Signal beam, and OPO Idler beam. The picoEmerald is software configurable to emit the following beam combinations at its output port: (1) Signal and 1032 nm; (2) Signal and Idler; (3) Signal, Idler, and 1032 nm.

Turning Complexity into a Turn-Key System

The light source is the most crucial and complex component of a SRS or CARS microscopy system. Proper setup and calibration are essential for  accurate and reproducible imaging. picoEmerald is a turn-key system combining user-friendly automation features and the utility of open-architecture light sources in a single box.

Applications

  • Stimulated Raman Spectroscopy (SRS)
  • Coherent Anti-Stokes Raman Spectroscopy (CARS)
  • SRS Microscopy of Vibrational Probes
  • Second Harmonics Imaging (SHG)
  • Pump-Probe Spectroscopy
  • Surface Enhanced Hyper Raman Spectroscopy (SEHRS)

Setup and Use with Microscopes

picoEmerald is compatible with nearly all popular confocal microscope systems. The current publication list names at least those configurations:

  • Home-built setups
  • Leica SP-Series
  • Olympus FV-Series
  • Nikon Ti-U Platform
  • Thorlabs Multiphoton
  • Zeiss LSM-Series
  • Horiba

By integrating SRS and CARS technology into Leica’s confocal SP5/SP8 microscopy system, Leica Microsystems has tightly integrated the picoEmerald into their LAS AF system software. Similary tight software integration is also available with Thorlabs’ multi-photon microscopes. Software integration into other third-party microscopes or home-built setups is also supported. Ethernet TCP/IP and serial RS232 interfaces are available with picoEmerald for this purpose. APE’s user-friendly automation combined with a graphical user interface (GUI) also makes it convenient when using picoEmerald and microscope as independent instruments, without the need for software integration.


Introduction to Stimulated Raman

Stimulated Raman Scattering (SRS) is based on the effect that excited molecules emit spontaneous Raman scattering, SRS is a further development of CARS. In the event of two different laser beams with a frequency difference which matches the vibrational frequency, the Raman signal will be amplified. So this process is not spontaneously anymore, it is stimulated.

This technique requires two laser beams. A Pump and a Stokes beam. One of these beams must be tuneable in order to meet the difference of the frequencies, so that the molecules can be excited into the virtual state and to bring it to the vibrational state. As at CARS, the molecules are only excited if the frequency coincides with the vibrational resonance.

The tuneable Pump beam gets a loss in intensity after excitation of the molecules (stimulated Raman loss – SRL). On the opposite, the intensity of the non-tuneable Stokes beam increases (stimulated Raman gain – SRG).

The different intensities between input Pump beam and output Pump beam are very low. So low, that the true measurement signal is lost in the noise. To measure this difference, the lock-in technique is used. For this the Stokes beam is modulated to a fixed frequency by an Electro-Optical Modulator (EOM). APE has integrated such EOM into picoEmerald.

Unlike CARS, SRS provides results with no non-resonant background. The assignments of CARS spectra are more complicated and thus the interpretation is more susceptible to errors. SRS is based on spontaneously Raman scattering and so the obtained SRS spectra are almost identical with spectra of spontaneously Raman scattering. Furthermore, SRS signal is directly linearly dependent to the concentration.

Coherent Anti-Stokes Raman Scattering (CARS)

Stimulated Raman Scattering (SRS)

Specifications

Additional Features

picoEmerald
Wavelength 1 (Stokes)1032 nm ± 1.5 nm
Wavelength 2 (Pump - Signal)700 nm … 990 nm
Wavelength 3 (Idler)1080 nm … 1950 nm
Power 1 (Stokes)>700 mW unmodulated
Power 2 (Pump - Signal)>700 mW at 800 nm
Power 3 (Idler)>400 mW at 1250 nm
∆v Pump - Stokes400 cm-1 … 4500 cm-1
∆v Pump - Idler800 cm-1 … 9000 cm-1
Spectral bandwidth~10 cm-1 (Pump - Signal and Stokes)
Pulse width~2 ps (Pump - Signal and Stokes)
Repetition rate80 MHz ± 0.5 MHz
NoiseShot noise limited (-161 dBc/Hz) >10 MHz for Pump - Signal
Beam parameters:
Pointing stability<100 µrad per 100 nm
(typical 100 µrad over entire range)
M2<1.2 for Pump - Signal, typical 1.2 for Stokes
Ellipticity<20 %
PolarizationLinear, horizontal >100:1
Beam divergence1.0 mrad ± 0.2 mrad at 800 nm and Stokes
Beam waist diameter1.2 mm ± 0.2 mm at 800 nm, 1.7 mm ± 0.2 mm for Stokes
Features:
Software configurable output modes1. Signal and 1032 nm, or
2. Signal and Idler, or
3. Signal, Idler and 1032 nm
respectively with overlap in space and time
Wavelength measurementIntegrated spectrometer for Pump - Signal wavelength
Power attenuatorsIntegrated for Pump - Signal and Stokes, indepedent for each beam
Wavelength sweep functionStart/End function, user-defined holding time, trigger function
Max. step size: 2 nm
Tuning speed: ~5 s per wavelength step
Remote controlPossible via USB, Ethernet TCP/IP or RS232
Options:
SRS modulatorEOM with resonant fixed modulation frequency of 20 MHz
Built-in and controllable with the same software
1032 nm beam modualted power: 300 mW
High power for 1032 nm beam2 W (unmodulated), 1 W (modulated)
Long pulse / Narrow-bandwidth option~4.5 ps / ~5 cm-1 Pump - Signal
~6.5 ps / ~10 cm-1 Stokes
Additional IR output portAdditional 1032 nm beam output for pumping another OPO (Levante IR ps)
Wavelength: 1032 nm ± 1.5 nm
Power: >4 W
Spectral bandwidth: ~10 cm-1
Pulse width: ~2 ps (~6.5 ps optional)
Repetition rate: 80 MHz ± 0.5 MHz
  • Stimulated Raman Scattering + Coherent Anti-Stokes Raman Spectroscopy with one device
  • Automated optical delay management to compensation for microscope dispersion
  • Wavelength scan / sweep function for fast spectra acquisition
  • Independent power control for 1032 nm beam and Signal beam
  • Remote-service via LAN interface
  • Optional: Wavelength extension from 210 nm – 10 μm
    (Realized by SHG, THG, FHG, or DFG; e.g. APE’s HarmoniXX)

Above: Typical Signal and Idler power vs. wavelength

Datasheets & Brochures

List of peer-reviewed publications

The following section provides a selection of relevant links and further reading on the picoEmerald, a fully automated two-color laser source from APE. Specifically designed to meet the needs of various imaging and spectroscopic techniques such as CARS, SRS, multimodal imaging, and SHG/multiphoton fluorescence, the picoEmerald platform enables label-free investigation of samples using Raman-based microscopy and spectroscopy techniques. These techniques exploit the intrinsic vibrational contrast between different molecules and their atomic bonds. The narrow bandwidth of the picosecond pulses emitted by picoEmerald provides an ideal balance between high spectral resolution and high-intensity, low-noise signals. The system is offered as a one-box, turnkey device equipped with a spectrometer, an electro-optical modulator (EOM), and sensors for temporal and spatial overlap. In addition to Raman-based applications, this light source is also valuable in quantum photonics research. For example, quantum dots can be precisely excited with narrow-band pulses, especially when combined with a spectral slicer (pulseSlicer) or pulse picker (pulseSelect) also available from APE. This setup provides optimal pulses for ultra-narrow-band single-state excitation of biexcitons. The following resources provide additional insight and technical details on the technologies and applications described.


YearApplicationAuthorsTitleJournalDoi
2024SRSRensonnet, Aurélie and Tipping, William J. and Malherbe, Cedric and Faulds, Karen and Eppe, Gauthier and Graham, DuncanSpectral fingerprinting of cellular lipid droplets using stimulated Raman scattering microscopy and chemometric analysisAnalysthttps://doi.org/10.1039/D3AN01684F
2024SRSLi, Yajuan and Munoz-Mayorga, Daniel and Nie, Yuhang and Kang, Ningxin and Tao, Yuren and Lagerwall, Jessica and Pernaci, Carla and Curtin, Genevieve and Coufal, Nicole G. and Mertens, Jerome and Shi, Lingyan and Chen, XuMicroglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPKCell Metabolismhttps://doi.org/10.1016/j.cmet.2024.03.014
2024SRSZhang, Wenxu and Li, Yajuan and Fung, Anthony A. and Li, Zhi and Jang, Hongje and Zha, Honghao and Chen, Xiaoping and Gao, Fangyuan and Wu, Jane Y. and Sheng, Huaxin and Yao, Junjie and Skowronska-Krawczyk, Dorota and Jain, Sanjay and Shi, LingyanMulti-molecular hyperspectral PRM-SRS microscopyNature Communicationshttps://doi.org/10.1038/s41467-024-45576-6
2024CARSHaney, Michael S. and Pálovics, Róbert and Munson, Christy Nicole and Long, Chris and Johansson, Patrik K. and Yip, Oscar and Dong, Wentao and Rawat, Eshaan and West, Elizabeth and Schlachetzki, Johannes C. M. and Tsai, Andy and Guldner, Ian Hunter and Lamichhane, Bhawika S. and Smith, Amanda and Schaum, Nicholas and Calcuttawala, Kruti and Shin, Andrew and Wang, Yung-Hua and Wang, Chengzhong and Koutsodendris, Nicole and Serrano, Geidy E. and Beach, Thomas G. and Reiman, Eric M. and Glass, Christopher K. and Abu-Remaileh, Monther and Enejder, Annika and Huang, Yadong and Wyss-Coray, TonyAPOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microgliaNaturehttps://doi.org/10.1038/s41586-024-07185-7
2024SRSDayton, Hannah and Kiss, Julie and Wei, Mian and Chauhan, Shradha and LaMarre, Emily and Cornell, William Cole and Morgan, Chase J. and Janakiraman, Anuradha and Min, Wei and Tomer, Raju and Price-Whelan, Alexa and Nirody, Jasmine A. and Dietrich, Lars E. P.Cellular arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilmsPLOS Biologyhttps://doi.org/10.1371/journal.pbio.3002205
2024quantum dotsVajner, Daniel A. and Holewa, Paweł and Zięba-Ostój, Emilia and Wasiluk, Maja and von Helversen, Martin and Sakanas, Aurimas and Huck, Alexander and Yvind, Kresten and Gregersen, Niels and Musiał, Anna and Syperek, Marcin and Semenova, Elizaveta and Heindel, TobiasOn-Demand Generation of Indistinguishable Photons in the Telecom C-Band Using Quantum Dot DevicesACS Photonicshttps://doi.org/10.1021/acsphotonics.3c00973
2024CARS, SHG, TPEFSantos, Priscila Dayane de Freitas and Keshanidokht, Shaghayegh and Kumar, Saket and Clausen, Mathias Porsmose and Via, Matias Alejandro and Favaro-Trindade, Carmen Sílvia and Andersen, Mogens Larsen and Risbo, JensA novel low-temperature procedure for oleogelation of heat-sensitive oils: Oleogels based on tucumã oil and ethyl celluloseLWThttps://doi.org/10.1016/j.lwt.2024.115776
2024SRS, super resolutionJang, Hongje and Li, Yajuan and Wu, Shuang and Shi, LingyanSuper-Resolution Stimulated Raman Scattering Microscopy with Graphical User Interface-Supported A-PoDCurrent Protocolshttps://doi.org/10.1039/D3AN01684F
2024SRSSwiatlowska, Pamela and Tipping, William and Marhuenda, Emilie and Severi, Paolo and Fomin, Vitalay and Yang, Zhisheng and Xiao, Qingzhong and Graham, Duncan and Shanahan, Cathy and Iskratsch, ThomasHypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam CellsAdv. Sci.https://doi.org/10.1002/advs.202308686
2024SRS, SEMLapointe, Adrien and Kocademir, Mustafa and Bergman, Paavo and Ragupathy, Imaiyan Chitra and Laumann, Michael and Underwood, Graham J. C. and Zumbusch, Andreas and Spiteller, Dieter and Kroth, Peter G.Characterization of polyphosphate dynamics in the widespread freshwater diatom Achnanthidium minutissimum under varying phosphorus suppliesJ. Phycol.https://doi.org/10.1111/jpy.13423
2023SRS, SHG, TPEFBagheri, Pegah and Hoang, Khang and Kuo, Chan-Yu and Trivedi, Hetvi and Jang, Hongje and Shi, LingyanBioorthogonal Chemical Imaging of Cell Metabolism Regulated by Aromatic Amino AcidsJoVEhttps://doi.org/10.3791/65121
2023CARSSalim, Malinda and MacGibbon, Alastair K. H. and Nowell, Cameron J. and Clulow, Andrew J. and Boyd, Ben J.Influence of Casein and Milk Phospholipid Emulsifiers on the Digestion and Self-Assembled Structures of Milk LipidsColloids Interfaceshttps://doi.org/10.3390/colloids7030056
2023SRSBraddick, Henry J. and Tipping, William J. and Wilson, Liam T. and Jaconelli, Harry S. and Grant, Emma K. and Faulds, Karen and Graham, Duncan and Tomkinson, Nicholas C. O.Determination of Intracellular Esterase Activity Using Ratiometric Raman Sensing and Spectral Phasor AnalysisAnal. Chem.https://doi.org/10.1021/acs.analchem.2c05708
2023CARSCorreia, Catarina Mendes and Præstholm, Stine Marie and Havelund, Jesper Foged and Pedersen, Felix Boel and Siersbæk, Majken Storm and Ebbesen, Morten Frendø and Gerhart-Hines, Zach and Heeren, Joerg and Brewer, Jonathan and Larsen, Steen and Blagoev, Blagoy and Færgeman, Nils Joakim and Grøntved, LarsAcute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male MiceEndocrinologyhttps://doi.org/10.1210/endocr/bqad128
2023SRSLi, Yong and Townsend, Katherine M. and Dorn, Robert S. and Prescher, Jennifer A. and Potma, Eric O.Enhancing Alkyne-Based Raman Tags with a Sulfur LinkerJ. Phys. Chem. Bhttps://doi.org/10.1021/acs.jpcb.2c09093
2023SRSZhang, Yongqing and Zhou, Yihui and Fang, Wen and Zhu, Hanlin and Ye, Cunqi and Zhang, Delong and Lee, Hyeon JeongSpatial sterol metabolism unveiled by stimulated Raman imagingFrontiers in Chemistryhttps://doi.org/10.3389/fchem.2023.1166313
2023SHGTaieb, Mahdia and Ghannoum, Dima and Barré, Lydia and Ouzzine, MohamedXylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plateCell Death & Diseasehttps://doi.org/10.1038/s41419-023-05875-0
2023SRS, SHG, TPEFJia, Hao and Liu, Juan and Fang, Tinghe and Zhou, Zhen and Li, Ruihong and Yin, Wenzhen and Qian, Yao and Wang, Qi and Zhou, Wanhui and Liu, Chang and Sun, Dingcheng and Chen, Xun and Ouyang, Zheng and Dong, Jiahong and Wang, Yunfang and Yue, ShuhuaThe role of altered lipid composition and distribution in liver fibrosis revealed by multimodal nonlinear optical microscopyScience Advanceshttps://doi.org/10.1126/sciadv.abq2937
2023CARSSamuels, Fionna M.D. and Pearce, Kylie C. and Soderlund, Stephanie and Stich, Dominik G. and Bonnart, Remi and Volk, Gayle M. and Levinger, Nancy E.Direct observation of common cryoprotectant permeation into rice callus by CARS microscopyCell Reports Physical Sciencehttps://doi.org/10.1016/j.xcrp.2023.101469
2023CARS, SHG, TPEFPaul, Alexandra and Chanclón, Belén and Brännmark, Cecilia and Wittung-Stafshede, Pernilla and Olofsson, Charlotta S. and Asterholm, Ingrid Wernstedt and Parekh, Sapun H.Comparing lipid remodeling of brown adipose tissue, white adipose tissue, and liver after one-week high fat diet intervention with quantitative Raman microscopyJ Cell Biochemhttps://doi.org/10.1002/jcb.30372
2023SRSWang, Jie and Jia, Hao and Daniel, Geoffrey and Gao, Jie and Jiang, Xiaomei and Ma, Lingyu and Yue, Shuhua and Guo, Juan and Yin, YafangInsights into asynchronous changes of cell wall polymers accumulated in different cell types during conifer xylem differentiationCarbohydrate Polymershttps://doi.org/10.1016/j.carbpol.2023.121076
2023CARSVilms Pedersen, Simon and Brewer, Jonathan R. and Hedegaard, Martin A.B. and Arnspang Christensen, EvaSpectral Unmixing for Label-Free, In-Liquid Characterization of Biomass Microstructure and Biopolymer Content by Coherent Raman ImagingAnal. Chem.https://doi.org/10.1021/acs.analchem.2c02349
2023CARSKreckel, Heidi D. and Samuels, Fionna M. D. and Bonnart, Remi and Volk, Gayle M. and Stich, Dominik G. and Levinger, Nancy E.Tracking Permeation of Dimethyl Sulfoxide (DMSO) in Mentha × piperita Shoot Tips Using Coherent Raman MicroscopyPlantshttps://doi.org/10.3390/plants12122247
2023BonFireWang, Haomin and Lee, Dongkwan and Cao, Yulu and Bi, Xiaotian and Du, Jiajun and Miao, Kun and Wei, LuBond-selective fluorescence imaging with single-molecule sensitivityNature Photonicshttps://doi.org/10.1038/s41566-023-01243-8
2023SRSLang, Xiaoqi and Gao, Xin and Wei, Mian and Qian, Naixin and Min, WeiBioorthogonal chemical imaging of solid lipid nanoparticles with minimal labeling by stimulated Raman scattering microscopyNatural Scienceshttps://doi.org/10.1002/ntls.202103304
20232PLCao, Xiumian and Peng, Jiang and Wang, Wenquan and Xu, Weiqing and Xu, ShupingAn elastic luminescent organic single crystal with linear and nonlinear optical waveguide propertiesDyes and Pigmentshttps://doi.org/10.1016/j.dyepig.2023.111531
2023SHGGhimire, Ganesh and Ulaganathan, Rajesh Kumar and Tempez, Agnès and Ilchenko, Oleksii and Unocic, Raymond R. and Heske, Julian and Miakota, Denys I. and Xiang, Cheng and Chaigneau, Marc and Booth, Tim and Bøggild, Peter and Thygesen, Kristian S. and Geohegan, David B. and Canulescu, StelaMolybdenum Disulfide Nanoribbons with Enhanced Edge Nonlinear Response and PhotoresponsivityAdv. Mater.https://doi.org/10.1002/adma.202302469
2023SRSLi, Yajuan and Chang, Phyllis and Sankaran, Shriya and Jang, Hongje and Nie, Yuhang and Zeng, Audrey and Hussain, Sahran and Wu, Jane Y. and Chen, Xu and Shi, LingyanBioorthogonal Stimulated Raman Scattering Imaging Uncovers Lipid Metabolic Dynamics in Drosophila Brain During AgingGEN Biotechnologyhttps://doi.org/10.1089/genbio.2023.0017
2023Quantum, squeezed lightLi, Zhihao and Liu, Jun and Guo, Fengjuan and Zhao, Lujie and Qin, Zhongzhong and Ma, Rong20 MHz resonant photodetector for the homodyne measurement of picosecond pulsed squeezed lightOpt. Continuumhttps://doi.org/10.1364/OPTCON.481271
2023SHGDavidson, Callam T. and Miller, Eileen and Muir, Morwenna and Dawson, John C. and Lee, Martin and Aitken, Stuart and Serrels, Alan and Webster, Scott P. and Homer, Natalie Z. M. and Andrew, Ruth and Brunton, Valerie G. and Hadoke, Patrick W. F. and Walker, Brian R.11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosisPLOS ONEhttps://doi.org/10.1371/journal.pone.0255709
2023CARSGordeev, Georgy and Lafeta, Lucas and Flavel, Benjamin S. and Jorio, Ado and Malard, Leandro M.Excitonic Resonances in Coherent Anti-Stokes Raman Scattering from Single-Walled Carbon NanotubesJ. Phys. Chem. Chttps://doi.org/10.1021/acs.jpcc.3c05696
2023CARSShayan, Mahdis and Huang, Michelle S. and Navarro, Renato and Chiang, Gladys and Hu, Caroline and Oropeza, Beu P. and Johansson, Patrik K. and Suhar, Riley A. and Foster, Abbygail A. and LeSavage, Bauer L. and Zamani, Maedeh and Enejder, Annika and Roth, Julien G. and Heilshorn, Sarah C. and Huang, Ngan F.Elastin-like protein hydrogels with controllable stress relaxation rate and stiffness modulate endothelial cell functionJ Biomed Mater Reshttps://doi.org/10.1002/jbm.a.37520
2023CARS, SHG, TPEFIachina, Irina and Eriksson, André H. and Bertelsen, Malene and Petersson, Karsten and Jansson, Jörgen and Kemp, Pernille and Engell, Karen M. and Brewer, Jonathan R. and Nielsen, Kim T.Dissolvable microneedles for transdermal drug delivery showing skin penetration and modified drug releaseEuropean Journal of Pharmaceutical Scienceshttps://doi.org/10.1016/j.ejps.2023.106371
2023CARSPennetzdorfer, Nina and Popescu, Medeea C. and Haddock, Naomi L. and Dupuy, Fannie and Kaber, Gernot and Hargil, Aviv and Johansson, Patrik K. and Enejder, Annika and Bollyky, Paul L.Bacterial outer membrane vesicles bound to bacteriophages modulate neutrophil responses to bacterial infectionFrontiers in Cellular and Infection Microbiologyhttps://doi.org/10.3389/fcimb.2023.1250339
2023CARSDianat, Mariam and Münchberg, Ute and Blank, Lars M. and Freier, Erik and Ebert, Birgitta E.Non-invasive monitoring of microbial triterpenoid production using nonlinear microscopy techniquesFrontiers in Bioengineering and Biotechnologyhttps://doi.org/10.3389/fbioe.2023.1106566
2023SRS, TPEF, SHGLi, Zhi and Nguyen, Chloe and Jang, Hongje and Hoang, David and Min, SoeSu and Ackerstaff, Ellen and Koutcher, Jason A. and Shi, LingyanMultimodal imaging of metabolic activities for distinguishing subtypes of breast cancerBiomed. Opt. Expresshttps://doi.org/10.1364/BOE.500252
2023CARS, FTIRKeshanidokht, Shaghayegh and Kumar, Saket and Thulstrup, Peter Waaben and Via, Matias Alejandro and Clausen, Mathias Porsmose and Risbo, JensThermo-responsive behavior of glycerol-plasticized oleogels stabilized by zeinFood Hydrocolloidshttps://doi.org/10.1016/j.foodhyd.2023.108582
2023SRS, STORM, STED, AFMStephens, Amberley D. and Villegas, Ana Fernandez and Chung, Chyi Wei and Vanderpoorten, Oliver and Pinotsi, Dorothea and Mela, Ioanna and Ward, Edward and McCoy, Thomas M. and Cubitt, Robert and Routh, Alexander F. and Kaminski, Clemens F. and Kaminski Schierle, Gabriele S.α-Synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased lipid-associated fibril uptake into iPSC-derived neuronsCommunications Biologyhttps://doi.org/10.1038/s42003-023-04884-1
2023SRSAgrawal, Rishi R. and Larrea, Delfina and Xu, Yimeng and Shi, Lingyan and Zirpoli, Hylde and Cummins, Leslie G. and Emmanuele, Valentina and Song, Donghui and Yun, Taekyung D. and Macaluso, Frank P. and Min, Wei and Kernie, Steven G. and Deckelbaum, Richard J. and Area-Gomez, EstelaAlzheimer’s-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain InjuryCellular and Molecular Neurobiologyhttps://doi.org/10.1007/s10571-022-01299-0
2023SRSJang, Hongje and Li, Yajuan and Fung, Anthony A. and Bagheri, Pegah and Hoang, Khang and Skowronska-Krawczyk, Dorota and Chen, Xiaoping and Wu, Jane Y. and Bintu, Bogdan and Shi, LingyanSuper-resolution SRS microscopy with A-PoDNature Methodshttps://doi.org/10.1038/s41592-023-01779-1
2023SRSZhou, Yusen and Zhang, Tian and Wang, Xiaocui and Wu, Wenqiang and Xing, Jingjing and Li, Zuliang and Qiao, Xin and Zhang, Chunrui and Wang, Xiaohang and Wang, Guangshun and Li, Wenhui and Bai, Shenglong and Li, Zhi and Suo, Yuanzhen and Wang, Jiajia and Niu, Yanli and Zhang, Junli and Lan, Chen and Hu, Zhubing and Li, Baozhu and Zhang, Xuebin and Wang, Wei and Galbraith, David W. and Chen, Yuhang and Guo, Siyi and Song, Chun-PengA maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesisNature Communicationshttps://doi.org/10.1038/s41467-023-40013-6
2023SRSPapsdorf, Katharina and Miklas, Jason W. and Hosseini, Amir and Cabruja, Matias and Morrow, Christopher S. and Savini, Marzia and Yu, Yong and Silva-García, Carlos G. and Haseley, Nicole R. and Murphy, Luke Meraz and Yao, Pallas and de Launoit, Elisa and Dixon, Scott J. and Snyder, Michael P. and Wang, Meng C. and Mair, William B. and Brunet, AnneLipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acidsNature Cell Biologyhttps://doi.org/10.1038/s41556-023-01136-6
2023SHG, TPEFPukaluk, Anna and Wolinski, Heimo and Viertler, Christian and Regitnig, Peter and Holzapfel, Gerhard A. and Sommer, GerhardChanges in the microstructure of the human aortic adventitia under biaxial loading investigated by multi-photon microscopyActa Biomaterialiahttps://doi.org/10.1016/j.actbio.2023.02.027
2023CARS, SHGPhan, Vietxuan and Hathazi, Denisa and Preuße, Corinna and Czech, Artur and Freier, Erik and Shema, Gerta and Zahedi, René P. and Roos, AndreasMolecular mechanisms in chloroquine-exposed muscle cells elucidated by combined proteomic and microscopic studiesNeuropathol Appl Neurobiolhttps://doi.org/10.1111/nan.12877
2023SRSvon Krusenstiern, A. Nikolai and Robson, Ryan N. and Qian, Naixin and Qiu, Baiyu and Hu, Fanghao and Reznik, Eduard and Smith, Nailah and Zandkarimi, Fereshteh and Estes, Verna M. and Dupont, Marcel and Hirschhorn, Tal and Shchepinov, Mikhail S. and Min, Wei and Woerpel, K. A. and Stockwell, Brent R.Identification of essential sites of lipid peroxidation in ferroptosisNature Chemical Biologyhttps://doi.org/10.1038/s41589-022-01249-3
2023SRSEvans, Christopher R. and Smiley, Marina K. and Asahara Thio, Sean and Wei, Mian and Florek, Lindsey C. and Dayton, Hannah and Price-Whelan, Alexa and Min, Wei and Dietrich, Lars E. P.Spatial heterogeneity in biofilm metabolism elicited by local control of phenazine methylationProceedings of the National Academy of Scienceshttps://doi.org/10.1073/pnas.2313208120
2023SRSHislop, Ewan W. and Tipping, William J. and Faulds, Karen and Graham, DuncanLabel-Free Cytometric Evaluation of Mitosis via Stimulated Raman Scattering Microscopy and Spectral Phasor AnalysisAnal. Chem.https://doi.org/10.1021/acs.analchem.3c00212
2023SRSPieczara, Anna and Borek-Dorosz, Aleksandra and Buda, Szymon and Tipping, William and Graham, Duncan and Pawlowski, Robert and Mlynarski, Jacek and Baranska, MalgorzataModified glucose as a sensor to track the metabolism of individual living endothelial cells - Observation of the 1602 cm−1 band called “Raman spectroscopic signature of life”Biosensors and Bioelectronicshttps://doi.org/10.1016/j.bios.2023.115234
2023SRS, SHG, TPEF, SIMSBelsey, Natalie A. and Dexter, Alex and Vorng, Jean-Luc and Tsikritsis, Dimitrios and Nikula, Chelsea J. and Murta, Teresa and Tiddia, Maria-Vitalia and Zhang, Junting and Gurdak, Elzbieta and Trindade, Gustavo F. and Gilmore, Ian S. and Page, Leanne and Roper, Clive S. and Guy, Richard H. and Bettex, Mila BonchevaVisualisation of drug distribution in skin using correlative optical spectroscopy and mass spectrometry imagingJournal of Controlled Releasehttps://doi.org/10.1016/j.jconrel.2023.10.026
2023SRS, FluorescenceBaek, Suji and Nah, Sanghee and Park, Joo Yeon and Lee, Sang Ju and Kang, Yong Gil and Kwon, Seung Hae and Oh, Seung Jun and Lee, Kang Pa and Moon, Byung SeokA novel chalcone derivative exerts anticancer effects by promoting apoptotic cell death of human pancreatic cancer cellsBioorganic & Medicinal Chemistryhttps://doi.org/10.1016/j.bmc.2023.117458
2023TPEFHuo, Zepeng and Cao, Xiumian and Sun, Dong and Xu, Weiqing and Yang, Bai and Xu, ShupingCarbonized Polymer Dot Probe for Two-Photon Fluorescence Imaging of Lipid Droplets in Living Cells and TissuesACS Sens.https://doi.org/10.1021/acssensors.2c02678
2023SRS, CARSAnukrati Goel and Dimitrios Tsikritsis and Natalie A. Belsey and Ruth Pendlington and Stephen Glavin and Tao ChenMeasurement of chemical penetration in skin using Stimulated Raman scattering microscopy and multivariate curve resolution - alternating least squaresSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopyhttps://doi.org/10.1016/j.saa.2023.122639
2022SRSChen, Tao and Cao, Chen and Zhang, Jianyun and Streets, Aaron and Li, Tiejun and Huang, YanyiHistologically resolved multiomics enables precise molecular profiling of human intratumor heterogeneityPLOS Biologyhttps://doi.org/10.1371/journal.pbio.3001699
2022SRS, TPEFFung, Anthony A. and Hoang, Khang and Zha, Honghao and Chen, Derek and Zhang, Wenxu and Shi, LingyanImaging Sub-Cellular Methionine and Insulin Interplay in Triple Negative Breast Cancer Lipid Droplet MetabolismFrontiers in Oncologyhttps://doi.org/10.3389/fonc.2022.858017
2022CARSPirhonen, Juho and Szkalisity, Ábel and Hagström, Jaana and Kim, Yonghyo and Migh, Ede and Kovács, Mária and Hölttä, Maarit and Peränen, Johan and Seppänen, Hanna and Haglund, Caj and Gil, Jeovanis and Rezeli, Melinda and Malm, Johan and Horvath, Peter and Markó-Varga, György and Puolakkainen, Pauli and Ikonen, ElinaLipid Metabolic Reprogramming Extends beyond Histologic Tumor Demarcations in Operable Human Pancreatic CancerCancer Reshttps://doi.org/10.1158/0008-5472.CAN-22-0396
2022SRSMiao, Kun and Lin, Li-En and Qian, Chenxi and Wei, LuLabel-free Super-resolution Imaging Enabled by Vibrational Imaging of Swelled Tissue and AnalysisJoVEhttps://doi.org/10.3791/63824
2022CARSAhn, Yuri and Lee, Eun Jung and Luo, Enzhi and Choi, Junjeong and Kim, Ji Young and Kim, Suho and Kim, Se-Hwa and Bae, Yu Jeong and Park, Sujin and Lee, Jinu and Oh, Sang HoParticulate Matter Promotes Melanin Production through Endoplasmic Reticulum Stress‒Mediated IRE1α SignalingJournal of Investigative Dermatologyhttps://doi.org/10.1016/j.jid.2021.08.444
2022SHG, AFM, STEMRosa, Bárbara L. T. and Fujisawa, Kazunori and Santos, Joyce C. C. and Zhang, Tianyi and Matos, Matheus J. S. and Sousa, Frederico B. and Barbosa, Tiago C. and Lafeta, Lucas and Ramos, Sérgio L. L. M. and Carvalho, Bruno R. and Chacham, Helio and Neves, Bernardo R. A. and Terrones, Mauricio and Malard, Leandro M.Investigation of spatially localized defects in synthetic ${\mathrm{WS}}_{2}$ monolayersPhys. Rev. Bhttps://doi.org/10.1103/PhysRevB.106.115301
2022CARS, SRSDicko, Hamadou and Grünewald, Tilman A. and Ferrand, Patrick and Vidal-Dupiol, Jérémie and Teaniniuraitemoana, Vaihiti and Koua, Manaari Sham and le Moullac, Gilles and Le Luyer, Jérémy and Saulnier, Denis and Chamard, Virginie and Duboisset, JulienSub-micrometric spatial distribution of amorphous and crystalline carbonates in biogenic crystals using coherent Raman microscopyJournal of Structural Biologyhttps://doi.org/10.1016/j.jsb.2022.107909
2022CARSNavarro, Renato S. and Huang, Michelle S. and Roth, Julien G. and Hubka, Kelsea M. and Long, Chris M. and Enejder, Annika and Heilshorn, Sarah C.Tuning Polymer Hydrophilicity to Regulate Gel Mechanics and Encapsulated Cell MorphologyAdv. Healthcare Mater.https://doi.org/10.1002/adhm.202200011
2022SWIR, SERS, SEHRSOlson, Jacob E. and Yu, Jung Ho and Thimes, Rebekah L. and Camden, Jon P.Vibrational two-photon microscopy for tissue imaging: Short-wave infrared surface-enhanced resonance hyper-Raman scatteringJ. Biophotonicshttps://doi.org/10.1002/jbio.202100158
2022SRSTipping, William J. and Wilson, Liam T. and An, Connie and Leventi, Aristea A. and Wark, Alastair W. and Wetherill, Corinna and Tomkinson, Nicholas C. O. and Faulds, Karen and Graham, DuncanStimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug-cell interactionsChem. Sci.https://doi.org/10.1039/D1SC06976D
2022CARS, SHG, TPEFImperadore, Pamela and Galli, Roberta and Winterhalder, Martin J. and Zumbusch, Andreas and Uckermann, OrtrudImaging Arm Regeneration: Label-Free Multiphoton Microscopy to Dissect the Process in Octopus vulgarisFrontiers in Cell and Developmental Biologyhttps://doi.org/10.3389/fcell.2022.814746
2022TPEFHuo, Zepeng and Xu, Weiqing and Chen, Gang and Wang, Zizhun and Xu, ShupingSurface-state triggered solvatochromism of carbonized polymer dot and its two-photon luminescenceNano Researchhttps://doi.org/10.1007/s12274-021-3754-8
2022SRSLi, Yajuan and Bagheri, Pegah and Chang, Phyllis and Zeng, Audrey and Hao, Jie and Fung, Anthony and Wu, Jane Y. and Shi, LingyanDirect Imaging of Lipid Metabolic Changes in Drosophila Ovary During Aging Using DO-SRS MicroscopyFrontiers in Aginghttps://doi.org/10.3389/fragi.2021.819903
2022SRSGrünewald, Tilman A. and Checchia, Stefano and Dicko, Hamadou and Le Moullac, Gilles and Sham Koua, Manaarii and Vidal-Dupiol, Jeremie and Duboisset, Julien and Nouet, Julius and Grauby, Olivier and Di Michiel, Marco and Chamard, VirginieStructure of an amorphous calcium carbonate phase involved in the formation of Pinctada margaritifera shellsProceedings of the National Academy of Scienceshttps://doi.org/10.1073/pnas.2212616119
2022SRSLi, Yajuan and Zhang, Wenxu and Fung, Anthony A. and Shi, LingyanDO-SRS imaging of diet regulated metabolic activities in Drosophila during aging processesAging Cellhttps://doi.org/10.1111/acel.13586
2022SRS, CARSJulien Duboisset and Patrick Ferrand and Arthur Baroni and Tilman A. Grünewald and Hamadou Dicko and Olivier Grauby and Jeremie Vidal-Dupiol and Denis Saulnier and Le Moullac Gilles and Martin Rosenthal and Manfred Burghammer and Julius Nouet and Corinne Chevallard and Alain Baronnet and Virginie ChamardAmorphous-to-crystal transition in the layer-by-layer growth of bivalve shell prismsActa Biomaterialiahttps://doi.org/10.1016/j.actbio.2022.01.024
2022CARS, TPEFKlug, Achim and McCullagh, Elizabeth A. and Poleg, Shani and Stich, Dominik and Moldovan, RaduCoherent Anti-Stokes Raman Spectroscopy (CARS) Application for Imaging Myelination in Brain SlicesJoVEhttps://doi.org/10.3791/64013
2022upconversionDuan, Jiaru and Liu, Yanping and Zhang, Yongqing and Chen, Zeng and Xu, Xuehui and Ye, Lei and Wang, Zukun and Yang, Yang and Zhang, Delong and Zhu, HaimingEfficient solid-state infrared-to-visible photon upconversion on atomically thin monolayer semiconductorsScience Advanceshttps://doi.org/10.1126/sciadv.abq4935
2022CARSAlmer, Gunter and Opriessnig, Peter and Wolinski, Heimo and Sommer, Gerhard and Diwoky, Clemens and Lechleitner, Margarete and Kolb, Dagmar and Bubalo, Vladimir and Brunner, Markus S. and Schwarz, Andreas N. and Leitinger, Gerd and Schoiswohl, Gabriele and Marsche, Gunther and Niedrist, Tobias and Schauer, Silvia and Oswald, Wolfgang and Groselj-Strele, Andrea and Paar, Margret and Cvirn, Gerhard and Hoefler, Gerald and Rechberger, Gerald N. and Herrmann, Markus and Frank, Saša and Holzapfel, Gerhard A. and Kratky, Dagmar and Mangge, Harald and Hörl, Gerd and Tehlivets, OksanaDeficiency of B vitamins leads to cholesterol-independent atherogenic transformation of the aortaBiomedicine & Pharmacotherapyhttps://doi.org/10.1016/j.biopha.2022.113640
2022CARSVigor, Claire and Züllig, Thomas and Eichmann, Thomas O. and Oger, Camille and Zhou, Bingqing and Rechberger, Gerald N. and Hilsberg, Lucas and Trötzmüller, Martin and Pellegrino, Roberto M. and Alabed, Husam B.R. and Hartler, Jürgen and Wolinski, Heimo and Galano, Jean-Marie and Durand, Thierry and Spener, Friedrichα-Linolenic acid and product octadecanoids in Styrian pumpkin seeds and oils: How processing impacts lipidomes of fatty acid, triacylglycerol and oxylipin molecular structuresFood Chemistryhttps://doi.org/10.1016/j.foodchem.2021.131194
2022CARSKeshavarzi, Fatemeh and Knudsen, Nina Østergaard and Komjani, Niloufarsadat Mirmahdi and Ebbesen, Morten F. and Brewer, Jonathan R. and Jafarzadeh, Shadi and Thormann, EsbenEnhancing the sweat resistance of sunscreensSkin Res Technolhttps://doi.org/10.1111/srt.13115
2022SRSDeng, Dinghuan and Chen, Tao and Wang, Meng C.Chapter 31 - Biomedical applications of SRS microscopy in functional genetics and genomicsbook: Stimulated Raman Scattering Microscopyhttps://doi.org/10.1016/B978-0-323-85158-9.00017-8
2022SRSYerevanian, Armen and Murphy, Luke M. and Emans, Sinclair and Zhou, Yifei and Ahsan, Fasih M. and Baker, Daniel and Li, Sainan and Adedoja, Adebanjo and Cedillo, Lucydalila and Stuhr, Nicole L. and Gnanatheepam, Einstein and Dao, Khoi and Jain, Mohit and Curran, Sean P. and Georgakoudi, Irene and Soukas, Alexander A.Riboflavin depletion promotes longevity and metabolic hormesis in Caenorhabditis elegansAging Cellhttps://doi.org/10.1111/acel.13718
2022SREFXiong, Hanqing and Min, WeiChapter 13 - Stimulated Raman excited fluorescence (SREF) microscopy: Combining the best of two worldsbook: Stimulated Raman Scattering Microscopyhttps://doi.org/10.1016/B978-0-323-85158-9.00022-1
2022CARSAbedin, Shamsul and Li, Yong and Sifat, Abid Anjum and Roy, Khokan and Potma, Eric O.Enhancement of Molecular Coherent Anti-Stokes Raman Scattering with Silicon NanoantennasNano Lett.https://doi.org/10.1021/acs.nanolett.2c02040
2022SRSZhang, Weifeng and Sun, Hongyi and He, Shipei and Chen, Xun and Yao, Lin and Zhou, Liqun and Wang, Yi and Wang, Pu and Hong, WeiliCompound Raman microscopy for rapid diagnosis and antimicrobial susceptibility testing of pathogenic bacteria in urineFrontiers in Microbiologyhttps://doi.org/10.3389/fmicb.2022.874966
2022SRSShi, Lixue and Wei, Mian and Min, WeiHighly-Multiplexed Tissue Imaging with Raman DyesJoVEhttps://doi.org/10.3791/63547
2022SRS, RamanTentellino, Christian and Tipping, William J. and McGee, Leah M. C. and Bain, Laura M. and Wetherill, Corinna and Laing, Stacey and Tyson-Hirst, Izaak and Suckling, Colin J. and Beveridge, Rebecca and Scott, Fraser J. and Faulds, Karen and Graham, DuncanRatiometric imaging of minor groove binders in mammalian cells using Raman microscopyRSC Chem. Biol.https://doi.org/10.1039/D2CB00159D
2022SRSBrzozowski, K. and Matuszyk, E. and Pieczara, A. and Firlej, J. and Nowakowska, A.M. and Baranska, M.Stimulated Raman scattering microscopy in chemistry and life science - Development, innovation, perspectivesBiotechnology Advanceshttps://doi.org/10.1016/j.biotechadv.2022.108003
2022CARSTolstik, Elen and Ali, Nairveen and Guo, Shuxia and Ebersbach, Paul and Möllmann, Dorothe and Arias-Loza, Paula and Dierks, Johann and Schuler, Irina and Freier, Erik and Debus, Jörg and Baba, Hideo A. and Nordbeck, Peter and Bocklitz, Thomas and Lorenz, KristinaCARS Imaging Advances Early Diagnosis of Cardiac Manifestation of Fabry DiseaseInternational Journal of Molecular Scienceshttps://doi.org/10.3390/ijms23105345
2022TPEF, SHGAnna Pukaluk and Heimo Wolinski and Christian Viertler and Peter Regitnig and Gerhard A. Holzapfel and Gerhard SommerChanges in the microstructure of the human aortic medial layer under biaxial loading investigated by multi-photon microscopyActa Biomaterialiahttps://doi.org/10.1016/j.actbio.2022.08.017
2022SRSWu, Wanjie and He, Sicong and Wu, Junqiang and Chen, Congping and Li, Xuesong and Liu, Kai and Qu, Jianan Y.Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral windowNature Communicationshttps://doi.org/10.1038/s41467-022-29496-x
2022CARSGangfuß, Andrea and Czech, Artur and Hentschel, Andreas and Münchberg, Ute and Horvath, Rita and Töpf, Ana and O'Heir, Emily and Lochmüller, Hanns and Stehling, Florian and Kiewert, Cordula and Sickmann, Albert and Kuechler, Alma and Kaiser, Frank J. and Kölbel, Heike and Christiansen, Jon and Schara-Schmidt, Ulrike and Roos, AndreasHomozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involvementJ. Pathol.https://doi.org/10.1002/path.5812
2022CARSOrtner, Vinzent Kevin and Nguyen, Nhi and Brewer, Jonathan R. and Solovyeva, Vita and Haedersdal, Merete and Philipsen, Peter AlshedeFractional CO2 laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug deliveryLasers in Surgery and Medicinehttps://doi.org/10.1002/lsm.23541
2022SRSHislop, Ewan W. and Tipping, William J. and Faulds, Karen and Graham, DuncanLabel-Free Imaging of Lipid Droplets in Prostate Cells Using Stimulated Raman Scattering Microscopy and Multivariate AnalysisAnal. Chem.https://doi.org/10.1021/acs.analchem.2c00236
2022SRSTipping, William J. and Merchant, Andrew S. and Fearon, Rebecca and Tomkinson, Nicholas C. O. and Faulds, Karen and Graham, DuncanTemporal imaging of drug dynamics in live cells using stimulated Raman scattering microscopy and a perfusion cell culture systemRSC Chem. Biol.https://doi.org/10.1039/D2CB00160H
2022CARSShaghayegh Keshanidokht and Matias Alejandro Via and Cigdem Yucel Falco and Mathias Porsmose Clausen and Jens RisboZein-stabilized emulsions by ethanol addition; stability and microstructureFood Hydrocolloidshttps://doi.org/10.1016/j.foodhyd.2022.107973
2022SRSShi, Lixue and Wei, Mian and Miao, Yupeng and Qian, Naixin and Shi, Lingyan and Singer, Ruth A. and Benninger, Richard K. P. and Min, WeiHighly-multiplexed volumetric mapping with Raman dye imaging and tissue clearingNature Biotechnologyhttps://doi.org/10.1038/s41587-021-01041-z
2021SRSCassio Lima and Chrispian W. Theron and Howbeer Muhamadali and Douglas B. Kell and Royston GoodacreSpectral artefacts induced by moving targets in live hyperspectral stimulated Raman spectroscopy: The case of lipid droplets in yeast cellsClinical Spectroscopyhttps://doi.org/10.1016/j.clispe.2021.100014
2021SRSChitra Ragupathy, Imaiyan and Schweikhard, Volker and Zumbusch, AndreasMultivariate analysis of hyperspectral stimulated Raman scattering microscopy imagesJ Raman Spectroschttps://doi.org/10.1002/jrs.6184
2021SRS, SREFXiong, Hanqing and Qian, Naixin and Miao, Yupeng and Zhao, Zhilun and Chen, Chen and Min, WeiSuper-resolution vibrational microscopy by stimulated Raman excited fluorescenceLight: Science \& Applicationshttps://doi.org/10.1038/s41377-021-00518-5
2021SRS, TPEFBagheri, Pegah and Hoang, Khang and Fung, Anthony A. and Hussain, Sahran and Shi, LingyanVisualizing Cancer Cell Metabolic Dynamics Regulated With Aromatic Amino Acids Using DO-SRS and 2PEF MicroscopyFrontiers in Molecular Bioscienceshttps://doi.org/10.3389/fmolb.2021.779702
2021SHGSousa, Frederico B and Lafeta, Lucas and Cadore, Alisson R and Sahoo, Prasana K and Malard, Leandro MRevealing atomically sharp interfaces of two-dimensional lateral heterostructures by second harmonic generation2D Materialshttps://doi.org/10.1088/2053-1583/ac0731
2021SRSLi, Yajuan and Zhang, Wenxu and Fung, Anthony A. and Shi, LingyanDO-SRS imaging of metabolic dynamics in aging DrosophilaAnalysthttps://doi.org/10.1039/D1AN01638E
2021SRSBasu, Sankha S. and Stopka, Sylwia A. and Abdelmoula, Walid M. and Randall, Elizabeth C. and Gimenez-Cassina Lopez, Begoña and Regan, Michael S. and Calligaris, David and Lu, Fake F. and Norton, Isaiah and Mallory, Melissa A. and Santagata, Sandro and Dillon, Deborah A. and Golshan, Mehra and Agar, Nathalie Y. R.Interim clinical trial analysis of intraoperative mass spectrometry for breast cancer surgerynpj Breast Cancerhttps://doi.org/10.1038/s41523-021-00318-5
2021TPEFDuong, Thuan T. and Isomäki, Antti and Paaver, Urve and Laidmäe, Ivo and Tõnisoo, Arvo and Yen, Tran T. and Kogermann, Karin and Raal, Ain and Heinämäki, Jyrki and Pham, Thi-Minh-HueNanoformulation and Evaluation of Oral Berberine-Loaded Liposomesmoleculeshttps://doi.org/10.3390/molecules26092591
2021SRS, TPEFMiao, Yupeng and Qian, Naixin and Shi, Lixue and Hu, Fanghao and Min, Wei9-Cyanopyronin probe palette for super-multiplexed vibrational imagingNature Communicationshttps://doi.org/10.1038/s41467-021-24855-6
2021SHGSchmidt, Charlotte Vinther and Plankensteiner, Lorenz and Clausen, Mathias Porsmose and Walhter, Anders Runge and Kirkensgaard, Jacob Judas Kain and Olsen, Karsten and Mouritsen, Ole G.Gastrophysical and chemical characterization of structural changes in cooked squid mantleJournal of Food Sciencehttps://doi.org/10.1111/1750-3841.15936
2021quantum dotsLettner, Thomas and Gyger, Samuel and Zeuner, Katharina D. and Schweickert, Lucas and Steinhauer, Stephan and Reuterskiöld Hedlund, Carl and Stroj, Sandra and Rastelli, Armando and Hammar, Mattias and Trotta, Rinaldo and Jöns, Klaus D. and Zwiller, ValStrain-Controlled Quantum Dot Fine Structure for Entangled Photon Generation at 1550 nmNano Lett.https://doi.org/10.1021/acs.nanolett.1c04024
2021SRS0Qian, Chenxi and Miao, Kun and Lin, Li-En and Chen, Xinhong and Du, Jiajun and Wei, LuSuper-resolution label-free volumetric vibrational imaginghttps://doi.org/10.1038/s41467-021-23951-x
2021CARSVia, Matias A. and Baechle, Mathias and Stephan, Alexander and Vilgis, Thomas A. and Clausen, Mathias P.Microscopic characterization of fatty liver-based emulsions: Bridging microstructure and texture in foie gras and patePhysics of Fluidshttps://doi.org/10.1063/5.0070998
2021CARS, TPEFLucas, Alexandra and Poleg, Shani and Klug, Achim and McCullagh, Elizabeth A.Myelination Deficits in the Auditory Brainstem of a Mouse Model of Fragile X SyndromeFrontiers in Neurosciencehttps://doi.org/10.3389/fnins.2021.772943
2021SRS, TPEFFonseca, Emerson A. and Lafeta, Lucas and Luiz Campos, João and Cunha, Renan and Barbosa, Alexandre and Romano-Silva, Marco A. and Vieira, Rafael and Malard, Leandro M. and Jorio, AdoMicro-Raman spectroscopy of lipid halo and dense-core amyloid plaques: aging process characterization in the Alzheimers disease APPswePS1ΔE9 mouse modelAnalysthttps://doi.org/10.1039/D1AN01078F
2021CARSDominique Dumas, Lucrèce Ebersold, Eric Battaglia, Carole Cossu-Leguille, Alexandre Specht, Bibiana Riquelme, Martín ToderiCars as a Method for the Detection of Toxic Pollutants in MIBA: The Case of Phthalates on Danio renio’s LarvaAdv Res Org Inorg Chem 2: 1003https://doi.org/10.54026/AROIC/1003
2021CARSDella Marina, Adela and Arlt, Annabelle and Schara-Schmidt, Ulrike and Depienne, Christel and Gangfuß, Andrea and Kölbel, Heike and Sickmann, Albert and Freier, Erik and Kohlschmidt, Nicolai and Hentschel, Andreas and Weis, Joachim and Czech, Artur and Grüneboom, Anika and Roos, AndreasPhenotypical and Myopathological Consequences of Compound Heterozygous Missense and Nonsense Variants in SLC18A3Cellshttps://doi.org/10.3390/cells10123481
2021SRS, CARS, TPEF, SHGAdams, Wilson R and Mehl, Brian and Lieser, Eric and Wang, Manqing and Patton, Shane and Throckmorton, Graham A and Jenkins, J Logan and Ford, Jeremy B and Gautam, Rekha and Brooker, Jeff and Jansen, E Duco and Mahadevan-Jansen, AnitaMulti-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissueScientific Reportshttps://doi.org/10.1038/s41598-021-86774-2
2021CARSArena, Roberta; Bisogno, Simona; Gasior, Lukasz; Rudnicka, Joanna; Bernhardt, Laura; Haaf, Thomas; Zacchini, Federica; Bochenek, Michal; Fic, Kinga; Bik, Ewelina; Baranska, Malgorzata; Bodzon-Kulakowska, Anna; Suder, Piotr; Depciuch, Joanna; Gurgul, Artur; Polanski, Zbigniew & Ptak, Grazyna E.Lipid droplets in mammalian eggs are utilized during embryonic diapauseProceedings of the National Academy of Scienceshttps://doi.org/10.1073/pnas.2018362118
2021SRSEmber, Katherine J.I. and Hunt, Fiona and Jamieson, Lauren E. and Hallett, John M. and Esser, Hannah and Kendall, Timothy J. and Clutton, R. Eddie and Gregson, Rachael and Faulds, Karen and Forbes, Stuart J. and Oniscu, Gabriel C. and Campbell, Colin J.Noninvasive Detection of Ischemic Vascular Damage in a Pig Model of Liver Donation After Circulatory DeathHepatologyhttps://doi.org/10.1002/hep.31701
2021CARSCadena del Castillo, Carla E. and Hannich, J. Thomas and Kaech, Andres and Chiyoda, Hirohisa and Brewer, Jonathan and Fukuyama, Masamitsu and Færgeman, Nils J. and Riezman, Howard and Spang, AnnePatched regulates lipid homeostasis by controlling cellular cholesterol levelsNature Communicationshttps://doi.org/10.1038/s41467-021-24995-9
2021CARSLee, Eun-Soo and Kim, Suho and Lee, Sang-Won and Jung, Jinsang and Lee, Sung H. and Na, Hye-Won and Kim, Hyoung-June and Hong, Yong D. and Park, Won S. and Lee, Tae G. and Jo, Dong-Gyu and Kim, Se-HwaMolecule-Resolved Visualization of Particulate Matter on Human Skin Using Multimodal Nonlinear Optical ImagingInt. J. Mol. Scihttps://doi.org/10.3390/ijms22105199
2021SRSSun, Na and Bu, Yufen and Pan, Chen and Wu, Xinyuan and Cao, Yuan and Jing, YanpingAnalyses of Microstructure and Dynamic Deposition of Cell Wall Components in Xylem Provide Insights into Differences between Two Black Poplar Cultivarsforestshttps://doi.org/10.3390/f12080972
2021SRS, TPEFWu, Wanjie and Li, Xuesong and Qu, Jianan Y. and He, SicongIn vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering MicroscopyJoVEhttps://doi.org/10.3791/63411
2021CARS, SHGGuan, Yuan and Enejder, Annika and Wang, Meiyue and Fang, Zhuoqing and Cui, Lu and Chen, Shih-Yu and Wang, Jingxiao and Tan, Yalun and Wu, Manhong and Chen, Xinyu and Johansson, Patrik K. and Osman, Issra and Kunimoto, Koshi and Russo, Pierre and Heilshorn, Sarah C. and Peltz, GaryA human multi-lineage hepatic organoid model for liver fibrosisNature Communicationshttps://doi.org/10.1038/s41467-021-26410-9
2021SRSAU Mutlu, Ayse Sena and AU Chen, Tao and AU Deng, Dinghuan and AU Wang, Meng C.Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering MicroscopyJoVEhttps://doi.org/10.3791/61870
2021SRSChen, Chen and Zhao, Zhilun and Qian, Naixin and Wei, Shixuan and Hu, Fanghao and Min, WeiMultiplexed live-cell profiling with Raman probesNature Communicationshttps://doi.org/10.1038/s41467-021-23700-0
2021CARSKohlschmidt, Nicolai and Elbracht, Miriam and Czech, Artur and Häusler, Martin and Phan, Vietxuan and Töpf, Ana and Huang, Kai-Ting and Bartok, Adam and Eggermann, Katja and Zippel, Stephanie and Eggermann, Thomas and Freier, Erik and Groß, Claudia and Lochmüller, Hanns and Horvath, Rita and Hajnóczky, György and Weis, Joachim and Roos, AndreasMolecular pathophysiology of human MICU1 deficiencyNeuropathol Appl Neurobiolhttps://doi.org/10.1111/nan.12694
2021CARSClulow, Andrew J.; Bakar, Syaza Y. Binte Abu; Salim, Malinda; Nowell, Cameron J.; Hawley, Adrian & Boyd, Ben J.Emulsions containing optimum cow milk fat and canola oil mixtures replicate the lipid self-assembly of human breast milk during digestionJournal of Colloid and Interface Sciencehttps://doi.org/10.1016/j.jcis.2020.11.067
2021SRSCunha, Renan; Lafeta, Lucas; Fonseca, Emerson A.; Barbosa, Alexandre; Romano-Silva, Marco A.; Vieira, Rafael; Jorio, Ado & Malard, Leandro M.Nonlinear and vibrational microscopy for label-free characterization of amyloid plaques in Alzheimer's disease modelAnalysthttps://doi.org/10.1039/D1AN00074H
2021FluorescenceFeng, Yuting; Liu, Weiji; Mercade-Prieto, Ruben & Chen, Xiao DongDye-protein interactions between Rhodamine B and whey proteins that affect the photoproperties of the dyeJournal of Photochemistry and Photobiology A: Chemistryhttps://doi.org/10.1016/j.jphotochem.2020.113092
2021CARS, TPEFGregersen, Sandra Beyer; Glover, Zachary James; Wiking, Lars; Simonsen, Adam Cohen; Bertelsen, Karina; Pedersen, Bent; Poulsen, Kristian Raaby; Andersen, Ulf & Hammershøj, MarianneMicrostructure and rheology of acid milk gels and stirred yoghurts –quantification of process-induced changes by auto- and cross correlation image analysisFood Hydrocolloidshttps://doi.org/10.1016/j.foodhyd.2020.106269
2021CARS, SHGHentschel, Andreas; Czech, Artur; Munchberg, Ute; Freier, Erik; Schara-Schmidt, Ulrike; Sickmann, Albert; Reimann, Jens & Roos, AndreasProtein signature of human skin fibroblasts allows the study of the molecular etiology of rare neurological diseasesOrphanet Journal of Rare Diseaseshttps://doi.org/10.1186/s13023-020-01669-1
2021SRSIşık, Doğuş and Joshi, Aaroh Anand and Guo, Xiao and Rancan, Fiorenza and Klossek, Andre and Vogt, Annika and Ruhl, Eckart and Hedtrich, Sarah and Klinger, DanielSulfoxide-functionalized nanogels inspired by the skin penetration properties of DMSOBiomater. Sci.https://doi.org/10.1039/D0BM01717E
2021CARSKeshavarzi, Fatemeh; Astergaard Knudsen, Nina; Brewer, Jonathan R.; Ebbesen, Morten F.; Mirmahdi Komjani, Niloufarsadat; Zajforoushan Moghaddam, Saeed; Jafarzadeh, Shadi & Thormann, EsbenIn vitro skin model for characterization of sunscreen substantivity upon perspirationInternational Journal of Cosmetic Sciencehttps://doi.org/10.1111/ics.12703
2021SRSLin, Li-En; Miao, Kun; Qian, Chenxi & Wei, LUHigh spatial-resolution imaging of label-free in vivo protein aggregates by VISTAAnalysthttps://doi.org/10.1039/D1AN00060H
2021SEHRSOlson, Jacob E.; Hu, Zhongwei; Best, Michael D.; Jensen, Lasse & Camden, Jon P.Surface-enhanced hyper-Raman scattering of Rhodamine 6G isotopologues: Assignment of lower vibrational frequenciesThe Journal of Chemical Physicshttps://doi.org/10.1063/5.0031679
2021CARS, SRSXu, Huimin; Zhao, Yuanyuan; Suo, Yuanzhen; Guo, Yayu; Man, Yi; Jing, Yanping; He, Xinqiang & Lin, JinxingA label-free, fast and high-specificity technique for plant cell wall imaging and composition analysisPlant Methodshttps://doi.org/10.1186/s13007-021-00730-9
2021SRSZhang, He; Guo, Zhonglong; Zhuang, Yan; Suo, Yuanzhen; Du, Jianmei; Gao, Zhaoxu; Pan, Jiawei; Li, Li; Wang, Tianxin; Xiao, Liang; Qin, Genji; Jiao, Yuling; Cai, Huaqing & Li, LeiMicroRNA775 regulates intrinsic leaf size and reduces cell wall pectin levels by targeting a galactosyltransferase gene in Arabidopsis.The Plant Cellhttps://doi.org/10.1093/plcell/koaa049
2021SRSZhao, Zhilun; Chen, Chen; Wei, Shixuan; Xiong, Hanqing; Hu, Fanghao; Miao, Yupeng; Jin, Tianwei & Min, WeiUltra-bright Raman dots for multiplexed optical imagingNature Communicationshttps://doi.org/10.1038/s41467-021-21570-0
2020SRSAudier, X.; Heuke, S.; Volz, P.; Rimke, I. & Rigneault, H.Noise in stimulated Raman scattering measurement: From basics to practiceAPL Photonicshttps://doi.org/10.1063/1.5129212
2020SHGCarvalho, Bruno R.; Wang, Yuanxi; Fujisawa, Kazunori; Zhang, Tianyi; Kahn, Ethan; Bilgin, Ismail; Ajayan, Pulickel M.; de Paula, Ana M.; Pimenta, Marcos A.; Kar, Swastik; Crespi, Vincent H.; Terrones, Mauricio & Malard, Leandro M.Nonlinear Dark-Field Imaging of One-Dimensional Defects in Monolayer DichalcogenidesNano Lettershttps://doi.org/10.1021/acs.nanolett.9b03795
2020CARSDo, Nhuan Thi; Kim, Suho; Kwak, Minjeong; Lee, Tae Geol; Jo, Dong-Gyu; Lee, Sang-Won & Kim, Se-HwaLength difference of multi-walled carbon nanotubes generates differential cytotoxic responsesJournal of Applied Toxicologyhttps://doi.org/10.1002/jat.4132
2020SRSCoto Hernández, Iván and Yang, Wenlong and Mohan, Suresh and Jowett, NateLabel-free histomorphometry of peripheral nerve by stimulated Raman spectroscopyMuscle Nervehttps://doi.org/10.1002/mus.26895
2020SRSDu, Jiajun; Su, Yapeng; Qian, Chenxi; Yuan, Dan; Miao, Kun; Lee, Dongkwan; Ng, Alphonsus H. C.; Wijker, Reto S.; Ribas, Antoni; Levine, Raphael D.; Heath, James R. & Wei, LuRaman-guided subcellular pharmaco-metabolomics for metastatic melanoma cellsNature Communicationshttps://doi.org/10.1038/s41467-020-18376-x
2020CARSHansen, Daniel; Brewer, Jonathan R.; Eiler, Johannes; Komjani, Niloufarsadat Mirmahdi; Hansen, Kristoffer & Thormann, EsbenWater Diffusion in Polymer Composites Probed by Impedance Spectroscopy and Time-Resolved Chemical ImagingACS Applied Polymer Materialshttps://doi.org/10.1021/acsapm.9b01107
2020TPEFHuo, Zepeng; Chen, Gang; Geng, Yijia; Cong, Lili; Pan, Lingyun; Xu, Weiqing & Xu, ShupingA two-photon fluorescence, carbonized polymer dot (CPD)-based, wide range pH nanosensor: a view from the surface stateNanoscalehttps://doi.org/10.1039/D0NR01543A
2020CARSKim, Jin Young; Liu, Zezhou; Weon, Byung Mook; Cohen, Tal; Hui, Chung-Yuen; Dufresne, Eric R. & Style, Robert W.Extreme cavity expansion in soft solids: Damage without fractureScience Advanceshttps://doi.org/10.1126/sciadv.aaz0418
2020quantum dotsKupko, Timm and von Helversen, Martin and Rickert, Lucas and Schulze, Jan-Hindrik and Strittmatter, André and Gschrey, Manuel and Rodt, Sven and Reitzenstein, Stephan and Heindel, TobiasTools for the performance optimization of single-photon quantum key distributionnpj Quantum Informationhttps://doi.org/10.1038/s41534-020-0262-8
2020SRSLee, Dongkwan; Du, Jiajun; Yu, Rona; Su, Yapeng; Heath, James R. & Wei, LuVisualizing Subcellular Enrichment of Glycogen in Live Cancer Cells by Stimulated Raman ScatteringAnalytical Chemistryhttps://doi.org/10.1021/acs.analchem.0c02348
2020quantum dotsLettner, Thomas; Zeuner, Katharina D.; Scholl, Eva; Huang, Huiying; Scharmer, Selim; da Silva, Saimon Filipe Covre; Gyger, Samuel; Schweickert, Lucas; Rastelli, Armando; Jons, Klaus D. & Zwiller, ValGaAs Quantum Dot in a Parabolic Microcavity Tuned to 87Rb D1ACS Photonicshttps://doi.org/10.1021/acsphotonics.9b01243
2020CARSLi, Huaiguang; Munchberg, Ute; Oughli, Alaa A.; Buesen, Darren; Lubitz, Wolfgang; Freier, Erik & Plumere, NicolasSuppressing hydrogen peroxide generation to achieve oxygen-insensitivity of a [NiFe] hydrogenase in redox active filmsNature Communicationshttps://doi.org/10.1038/s41467-020-14673-7
2020SRS, SR-GOLDLombardini, Alberto; Berto, Pascal; Duboisset, Julien; Andresen, Esben Ravn; Heuke, Sandro; Büttner, Edlef; Rimke, Ingo; Vergnole, Sebastien; Shinkar, Vasyl; de Bettignies, Philippe & Rigneault, HervèBackground-suppressed SRS fingerprint imaging with a fully integrated system using a single optical parametric oscillatorOpt. Expresshttps://doi.org/10.1364/OE.390381
2020CARSMarschallinger, Julia; Iram, Tal; Zardeneta, Macy; Lee, Song E.; Lehallier, Benoit; Haney, Michael S.; Pluvinage, John V.; Mathur, Vidhu; Hahn, Oliver; Morgens, David W.; Kim, Justin; Tevini, Julia; Felder, Thomas K.; Wolinski, Heimo; Bertozzi, Carolyn R.; Bassik, Michael C.; Aigner, Ludwig & Wyss-Coray, TonyLipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brainNature Neurosciencehttps://doi.org/10.1038/s41593-019-0566-1
2020SHGMartins, Guilherme M.; Fantini, Cristiano; Malard, Leandro M.; Coelho, Pamela O.; Moreira, Roberto L. & Dias, AndersonNew insights on the structural and optical-vibration properties of noncentrosymmetric lanthanides pyrogermanatesCeramics Internationalhttps://doi.org/10.1016/j.ceramint.2020.02.133
2020SRSMutlu, Ayse Sena; Gao, Shihong Max; Zhang, Haining & Wang, Meng C.Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegansNature Communicationshttps://doi.org/10.1038/s41467-020-15296-8
2020SRSOsorio-Blanco, Ernesto R.; Rancan, Fiorenza; Klossek, Andre; Nissen, Jan H.; Hoffmann, Luisa; Bergueiro, Julian; Riedel, Sebastian; Vogt, Annika; Ruhl, Eckart & Calderan, MarceloPolyglycerol-Based Thermoresponsive Nanocapsules Induce Skin Hydration and Serve as a Skin Penetration EnhancerACS Applied Materials \& Interfaceshttps://doi.org/10.1021/acsami.0c06874
2020CARSPazin, Wallance M.; Furini, Leonardo N.; Solovyeva, Vita; Lemma, Tibebe; Rubira, Rafael J. G.; Jorgensen, Bjarke; Constantino, Carlos J. L. & Brewer, Jonathan R.Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin CApplied Spectroscopyhttps://doi.org/10.1177/0003702820904456
2020SRSShi, Lixue; Liu, Xinwen; Shi, Lingyan; Stinson, H. Ted; Rowlette, Jeremy; Kahl, Lisa J.; Evans, Christopher R.; Zheng, Chaogu; Dietrich, Lars E. P. & Min, WeiMid-infrared metabolic imaging with vibrational probesNature Methodshttps://doi.org/10.1038/s41592-020-0883-z
2020CARSSingh, Avinash K.; Santra, Kalyan; Song, Xueyu; Petrich, Jacob W. & Smith, Emily A.Spectral Narrowing Accompanies Enhanced Spatial Resolution in Saturated Coherent Anti-Stokes Raman Scattering (CARS): Comparisons of Experiment and TheoryThe Journal of Physical Chemistry Ahttps://doi.org/10.1021/acs.jpca.0c02396
2020CARSSuhar, Riley A.; Marquardt, Laura M.; Song, Shang; Buabbas, Hana; Doulames, Vanessa M.; Johansson, Patrik K.; Klett, Katarina C.; Dewi, Ruby E.; Enejder, Annika M. K.; Plant, Giles W.; George, Paul M. & Heilshorn, Sarah C.Elastin-like Proteins to Support Peripheral Nerve Regeneration in Guidance ConduitsACS Biomaterials Science \& Engineeringhttps://doi.org/10.1021/acsbiomaterials.0c01053
2020CARSWagner, Carina; Hois, Victoria; Pajed, Laura; Pusch, Lisa-Maria; Wolinski, Heimo; Trauner, Michael; Zimmermann, Robert; Taschler, Ulrike & Lass, AchimLysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradationBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipidshttps://doi.org/10.1016/j.bbalip.2020.158730
2020SRSWilson, Liam T.; Tipping, William J.; Jamieson, Lauren E.; Wetherill, Corinna; Henley, Zoa; Faulds, Karen; Graham, Duncan; Mackay, Simon P. & Tomkinson, Nicholas C. O.A new class of ratiometric small molecule intracellular pH sensors for Raman microscopyAnalysthttps://doi.org/10.1039/D0AN00865F
2020SREFXiong, Hanqing & Min, WeiCombining the best of two worlds: Stimulated Raman excited fluorescenceThe Journal of Chemical Physicshttps://doi.org/10.1063/5.0030204
2020SRSXiong, Hanqing; Qian, Naixin; Zhao, Zhilun; Shi, Lingyan; Miao, Yupeng & Min, WeiBackground-free imaging of chemical bonds by a simple and robust frequency-modulated stimulated Raman scattering microscopyOpt. Expresshttps://doi.org/10.1364/OE.391016
2019CARSAljakouch, Karim; Hilal, Ziad; Daho, Ibrahim; Schuler, Martin; Krauß, Sascha D.; Yosef, Hesham K.; Dierks, Johann; Mosig, Axel; Gerwert, Klaus & El-Mashtoly, Samir F.Fast and Noninvasive Diagnosis of Cervical Cancer by Coherent Anti-Stokes Raman ScatteringAnalytical Chemistryhttps://doi.org/10.1021/acs.analchem.9b03395
2019TPEFFonseca, Emerson A.; Lafeta, Lucas; Cunha, Renan; Miranda, Hudson; Campos, Joao; Medeiros, Helton G.; Romano-Silva, Marco A.; Silva, Raigna A.; Barbosa, Alexandre S.; Vieira, Rafael P.; Malard, Leandro M. & Jorio, AdoA fingerprint of amyloid plaques in a bitransgenic animal model of Alzheimer's disease obtained by statistical unmixing analysis of hyperspectral Raman dataAnalysthttps://doi.org/10.1039/C9AN01631G
2019SRSGarcia-Bermudez, Javier; Baudrier, Lou; Bayraktar, Erol Can; Shen, Yihui; La, Konnor; Guarecuco, Rohiverth; Yucel, Burcu; Fiore, Danilo; Tavora, Bernardo; Freinkman, Elizaveta; Chan, Sze Ham; Lewis, Caroline; Min, Wei; Inghirami, Giorgio; Sabatini, David M. & Birsoy, KivancSqualene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell deathNaturehttps://doi.org/10.1038/s41586-019-0945-5
2019four-wave-mixingGeng, Yijia; Cong, Lili; Tian, Yu; Huo, Zepeng; Wang, Yinghui; Xing, Lu; Xu, Shuping; Liang, Chongyang & Xu, WeiqingSilver nanoparticle-enhanced four-wave mixing (FWM) imaging technique for visualizing sialic acid on cell membraneSensors and Actuators B: Chemicalhttps://doi.org/10.1016/j.snb.2019.127074
2019CARSGlover, Zachary J.; Ersch, Carsten; Andersen, Ulf; Holmes, Melvin J.; Povey, Megan J.; Brewer, Jonathan R. & Simonsen, Adam CohenSuper-resolution microscopy and empirically validated autocorrelation image analysis discriminates microstructures of dairy derived gelsFood Hydrocolloidshttps://doi.org/10.1016/j.foodhyd.2018.12.004
2019SHGGluais, Maude; Clouet, Johann; Fusellier, Marion; Decante, Cyrille; Moraru, Constantin; Dutilleul, Maeva; Veziers, Joëlle; Lesoeur, Julie; Dumas, Dominique; Abadie, Jerome; Hamel, Antoine; Bord, Eric; Chew, Sing Yian; Guicheux, Jerome & Visage, Catherine LeIn vitro and in vivo evaluation of an electrospun-aligned microfibrous implant for Annulus fibrosus repairBiomaterialshttps://doi.org/10.1016/j.biomaterials.2019.03.010
2019SRSHu, Fanghao; Shi, Lixue & Min, WeiBiological imaging of chemical bonds by stimulated Raman scattering microscopyNature Methodshttps://doi.org/10.1038/s41592-019-0538-0
2019CARSJensen, Brian B.; Glover, Zachary J.; Pedersen, Simon M.M.; Andersen, Ulf; Duelund, Lars & Brewer, Jonathan R.Label free noninvasive spatially resolved NaCl concentration measurements using Coherent Anti-Stokes Raman Scattering microscopy applied to butterFood Chemistryhttps://doi.org/10.1016/j.foodchem.2019.05.155
2019CARSKim, Suho; Lee, Eun-Soo; Lee, Sang-Won; Kim, Yong-Hoon; Lee, Chul-Ho; Jo, Dong-Gyu & Kim, Se-HwaSite-specific impairment of perivascular adipose tissue on advanced atherosclerotic plaques using multimodal nonlinear optical imagingProceedings of the National Academy of Scienceshttps://doi.org/10.1073/pnas.1902007116
2019SRS, TPEFLi, Xuesong; Li, Yan; Jiang, Meijuan; Wu, Wanjie; He, Sicong; Chen, Congping; Qin, Zhongya; Tang, Ben Zhong; Mak, Ho Yi & Qu, Jianan Y.Quantitative Imaging of Lipid Synthesis and Lipolysis Dynamics in Caenorhabditis elegans by Stimulated Raman Scattering MicroscopyAnalytical Chemistryhttps://doi.org/10.1021/acs.analchem.8b04875
2019SHGNiestrawska, Justyna A.; Regitnig, Peter; Viertler, Christian; Cohnert, Tina U.; Babu, Anju R. & Holzapfel, Gerhard A.The role of tissue remodeling in mechanics and pathogenesis of abdominal aortic aneurysmsActa Biomaterialiahttps://doi.org/10.1016/j.actbio.2019.01.070
2019SRSRamachandran, Prasanna V.; Savini, Marzia; Folick, Andrew K.; Hu, Kuang; Masand, Ruchi; Graham, Brett H. & Wang, Meng C.Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial ActivityDevelopmental Cellhttps://doi.org/10.1016/j.devcel.2018.12.022
2019SRSSchiessl, Konstanze T.; Hu, Fanghao; Jo, Jeanyoung; Nazia, Sakila Z.; Wang, Bryan; Price-Whelan, Alexa; Min, Wei & Dietrich, Lars E. P.Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilmsNature Communicationshttps://doi.org/10.1038/s41467-019-08733-w
2019CARSShahmoradian, Sarah H.; Lewis, Amanda J.; Genoud, Christel; Hench, Jurgen; Moors, Tim E.; Navarro, Paula P.; Castano-Diez, Daniel; Schweighauser, Gabriel; Graff-Meyer, Alexandra; Goldie, Kenneth N.; Sutterlin, Rosmarie; Huisman, Evelien; Ingrassia, Angela; Gier, Yvonne de; Rozemuller, Annemieke J. M.; Wang, Jing; Paepe, Anne De; Erny, Johannes; Staempfli, Andreas; Hoernschemeyer, Joerg; Grosseruschkamp, Frederik; Niedieker, Daniel; El-Mashtoly, Samir F.; Quadri, Marialuisa; Van IJcken, Wilfred F. J.; Bonifati, Vincenzo; Gerwert, Klaus; Bohrmann, Bernd; Frank, Stephan; Britschgi, Markus; Stahlberg, Henning; Van de Berg, Wilma D. J. & Lauer, Matthias E.Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranesNature Neurosciencehttps://doi.org/10.1038/s41593-019-0423-2
2019SREFShi, Lixue; Hu, Fanghao & Min, WeiOptical mapping of biological water in single live cells by stimulated Raman excited fluorescence microscopyNature Communicationshttps://doi.org/10.1038/s41467-019-12708-2
2019CARSSood, Disha; Tang-Schomer, Min; Pouli, Dimitra; Mizzoni, Craig; Raia, Nicole; Tai, Albert; Arkun, Knarik; Wu, Julian; Black, Lauren D.; Scheffler, Bjorn; Georgakoudi, Irene; Steindler, Dennis A. & Kaplan, David L.3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumorsNature Communicationshttps://doi.org/10.1038/s41467-019-12420-1
2019CARSTexada, Michael J.; Jorgensen, Anne F.; Christensen, Christian F.; Koyama, Takashi; Malita, Alina; Smith, Daniel K.; Marple, Dylan F. M.; Danielsen, E. Thomas; Petersen, Sine K.; Hansen, Jakob L.; Halberg, Kenneth A. & Rewitz, Kim F.A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretionNature Communicationshttps://doi.org/10.1038/s41467-019-09943-y
2019CARSTexada, Michael J.; Malita, Alina; Christensen, Christian F.; Dall, Kathrine B.; Faergeman, Nils J.; Nagy, Stanislav; Halberg, Kenneth A. & Rewitz, KimAutophagy-Mediated Cholesterol Trafficking Controls Steroid ProductionDevelopmental Cellhttps://doi.org/10.1016/j.devcel.2019.01.007
2019SRSTipping, William J.; Lee, Martin; Brunton, Valerie G.; Lloyd-Jones, Guy C. & Hulme, Alison N.Kinetic analysis of bioorthogonal reaction mechanisms using Raman microscopyFaraday Discuss.https://doi.org/10.1039/C9FD00057G
2019SRSVanden-Hehir, Sally; Cairns, Stefan A.; Lee, Martin; Zoupi, Lida; Shaver, Michael P.; Brunton, Valerie G.; Williams, Anna & Hulme, Alison N.Alkyne-Tagged PLGA Allows Direct Visualization of Nanoparticles In Vitro and Ex Vivo by Stimulated Raman Scattering MicroscopyBiomacromoleculeshttps://doi.org/10.1021/acs.biomac.9b01092
2019SRSWanjiku, Barbara; Yamamoto, Kenji; Klossek, Andre; Schumacher, Fabian; Pischon, Hannah; Mundhenk, Lars; Rancan, Fiorenza; Judd, Martyna M.; Ahmed, Muniruddin; Zoschke, Christian; Kleuser, Burkhard; Ruhl, Eckart & Schafer-Korting, MonikaQualifying X-ray and Stimulated Raman Spectromicroscopy for Mapping Cutaneous Drug PenetrationAnalytical Chemistryhttps://doi.org/10.1021/acs.analchem.9b00519
2019SREFXiong, Hanqing; Qian, Naixin; Miao, Yupeng; Zhao, Zhilun & Min, WeiStimulated Raman Excited Fluorescence Spectroscopy of Visible DyesJ. Phys. Chem. Lett.https://doi.org/10.1021/acs.jpclett.9b01289
2019SREFXiong, Hanqing; Shi, Lixue; Wei, Lu; Shen, Yihui; Long, Rong; Zhao, Zhilun & Min, WeiStimulated Raman excited fluorescence spectroscopy and imagingNature Photonicshttps://doi.org/10.1038/s41566-019-0396-4
2019CARSSaarinen, Jukka and Gütter, Friederike and Lindman, Mervi and Agopov, Mikael and Fraser-Miller, Sara J. and Scherließ, Regina and Jokitalo, Eija and Santos, Hélder A. and Peltonen, Leena and Isomäki, Antti and Strachan, Clare J.Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman ScatteringBiotechnol. J.https://doi.org/10.1002/biot.201800413
2019SRSZhang, Luyuan; Shi, Lingyan; Shen, Yihui; Miao, Yupeng; Wei, Mian; Qian, Naixin; Liu, Yinong & Min, WeiSpectral tracing of deuterium for imaging glucose metabolismNature Biomedical Engineeringhttps://doi.org/10.1038/s41551-019-0393-4
2019SRSZhu, Xiphias Ge; Puthenveedu, Shirony Nicholson; Shen, Yihui; La, Konnor; Ozlu, Can; Wang, Tim; Klompstra, Diana; Gultekin, Yetis; Chi, Jingyi; Fidelin, Justine; Peng, Tao; Molina, Henrik; Hang, Howard C.; Min, Wei & Birsoy, KivancCHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4Molecular Cellhttps://doi.org/10.1016/j.molcel.2019.01.037
2018CARS, SHGAbbott, Rosalyn D.; Borowsky, Francis E.; Alonzo, Carlo A.; Zieba, Adam; Georgakoudi, Irene & Kaplan, David L.Variability in responses observed in human white adipose tissue modelsJournal of Tissue Engineering and Regenerative Medicinehttps://doi.org/10.1002/term.2572
2018CARS, SRSBocklitz, T.; Meyer, T.; Schmitt, M.; Rimke, I.; Hoffmann, F.; von Eggeling, F.; Ernst, G.; Guntinas-Lichius, O. & Popp, J.Invited Article: Comparison of hyperspectral coherent Raman scattering microscopies for biomedical applicationsAPL Photonicshttps://doi.org/10.1063/1.5030159
2018SRSCheng, Qian; Wei, Lu; Liu, Zhe; Ni, Nan; Sang, Zhe; Zhu, Bin; Xu, Weiheng; Chen, Meijie; Miao, Yupeng; Chen, Long-Qing; Min, Wei & Yang, YuanOperando and three-dimensional visualization of anion depletion and lithium growth by stimulated Raman scattering microscopyNature Communicationshttps://doi.org/10.1038/s41467-018-05289-z
2018PL, SHGvon Dreifus, Driele; Alencar, Thonimar; Moreira, Maria; Silva, Eliel; Yeh, Chao-Hui; Chiu, Po-Wen; Pimenta, Marcos; Malard, Leandro & de Paula, AnaTwisted bilayer graphene photoluminescence emission peaks at van Hove singularitiesJournal of Physics Condensed Matterhttps://doi.org/10.1088/1361-648X/aab64b
2018CARSEbersbach, Paul; Stehle, Felix; Kayser, Oliver & Freier, ErikChemical fingerprinting of single glandular trichomes of Cannabis sativa by Coherent anti-Stokes Raman scattering (CARS) microscopyBMC Plant Biologyhttps://doi.org/10.1186/s12870-018-1481-4
2018SHGFaxholm, Peter Lionet; Schmidt, Charlotte Vinther; Bronnum, Louise Beck; Sun, Yi-Ting; Clausen, Mathias P.; Flore, Roberto; Olsen, Karsten & Mouritsen, Ole G.Squids of the North: Gastronomy and gastrophysics of Danish squidInternational Journal of Gastronomy and Food Sciencehttps://doi.org/10.1016/j.ijgfs.2018.11.002
2018SRSGaschler, Michael M.; Hu, Fanghao; Feng, Huizhong; Linkermann, Andreas; Min, Wei & Stockwell, Brent R.Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing FerroptosisACS Chemical Biologyhttps://doi.org/10.1021/acschembio.8b00199
2018CARSGonzález Coraspe, José Andrés; Weis, Joachim; Anderson, Mary E.; Manchberg, Ute; Lorenz, Kristina; Buchkremer, Stephan; Carr, Stephanie; Zahedi, Rene Peiman; Brauers, Eva; Michels, Hannah; Sunada, Yoshihide; Lochmäller, Hanns; Campbell, Kevin P.; Freier, Erik; Hathazi, Denisa & Roos, AndreasBiochemical and pathological changes result from mutated Caveolin-3 in muscleSkeletal Musclehttps://doi.org/10.1186/s13395-018-0173-y
2018CARSHan, Minyi; Clausen, Mathias; Christensen, Morten; Vossen, Els; Van Hecke, Thomas & Bertram, HanneEnhancing the health potential of processed meat: Effect of chitosan or carboxymethyl cellulose enrichment on inherent microstructure, water mobility and oxidation in a meat-based food matrixFood & Functionhttps://doi.org/10.1039/C8FO00835C
2018SRSHe, Sicong; An, Yitai; Li, Xuesong; Wei, Xiuqing; Sun, Qiqi; Wu, Zhenguo & Qu, Jianan Y.In vivo metabolic imaging and monitoring of brown and beige fatJournal of Biophotonicshttps://doi.org/10.1002/jbio.201800019
2018SRSHu, Fanghao; Zeng, Chen; Long, Rong; Miao, Yupeng; Wei, Lu; Xu, Qizhi & Min, WeiSupermultiplexed optical imaging and barcoding with engineered polyynesNature Methodshttps://doi.org/10.1038/nmeth.4578
2018SRSJi, Minbiao; Arbel, Michal; Zhang, Lili; Freudiger, Christian W.; Hou, Steven S.; Lin, Dongdong; Yang, Xinju; Bacskai, Brian J. & Xie, X. SunneyLabel-free imaging of amyloid plaques in Alzheimers disease with stimulated Raman scattering microscopyScience Advanceshttps://doi.org/10.1126/sciadv.aat7715
2018CARSOjarinta, Rami; Saarinen, Jukka; Strachan, Clare J.; Korhonen, Ossi & Laitinen, RiikkaPreparation and characterization of multi-component tablets containing co-amorphous salts: Combining multimodal non-linear optical imaging with established analytical methodsEuropean Journal of Pharmaceutics and Biopharmaceuticshttps://doi.org/10.1016/j.ejpb.2018.09.013
2018SEHRSOlson, Jacob E.; Tripp, Alicia; Linder, Michelle K.; Hu, Zhongwei; Detty, Michael R.; Jensen, Lasse & Camden, Jon P.Non-Condon Effects in the Resonance Hyper-Raman Scattering of Chalcogen-Substituted Rhodamine DerivativesThe Journal of Physical Chemistry Chttps://doi.org/10.1021/acs.jpcc.8b07507
20182PLPark, Joo H.; Park, Jisoo; Kim, Suho; Kim, Se-Hwa; Lee, Tae G.; Lee, Jae Y. & Wi, Jung-SubCharacterization and application of porous gold nanoparticles as 2-photon luminescence imaging agents: 20-fold brighter than gold nanorodsJournal of Biophotonicshttps://doi.org/10.1002/jbio.201700174
2018SRSRandall, Elizabeth C.; Emdal, Kristina B.; Laramy, Janice K.; Kim, Minjee; Roos, Alison; Calligaris, David; Regan, Michael S.; Gupta, Shiv K.; Mladek, Ann C.; Carlson, Brett L.; Johnson, Aaron J.; Lu, Fa-Ke; Xie, X. Sunney; Joughin, Brian A.; Reddy, Raven J.; Peng, Sen; Abdelmoula, Walid M.; Jackson, Pamela R.; Kolluri, Aarti; Kellersberger, Katherine A.; Agar, Jeffrey N.; Lauffenburger, Douglas A.; Swanson, Kristin R.; Tran, Nhan L.; Elmquist, William F.; White, Forest M.; Sarkaria, Jann N. & Agar, Nathalie Y. R.Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastomaNature Communicationshttps://doi.org/10.1038/s41467-018-07334-3
2018quantum dotsSchweickert, Lucas; Jons, Klaus D.; Zeuner, Katharina D.; Covre da Silva, Saimon Filipe; Huang, Huiying; Lettner, Thomas; Reindl, Marcus; Zichi, Julien; Trotta, Rinaldo; Rastelli, Armando & Zwiller, ValOn-demand generation of background-free single photons from a solid-state sourceApplied Physics Lettershttps://doi.org/10.1063/1.5020038
2018SRSShi, Lingyan; Shen, Yihui & Min, WeiInvited Article: Visualizing protein synthesis in mice with in vivo labeling of deuterated amino acids using vibrational imagingAPL Photonicshttps://doi.org/10.1063/1.5028134
2018SRSShi, Lixue; Xiong, Hanqing; Shen, Yihui; Long, Rong; Wei, Lu & Min, WeiElectronic Resonant Stimulated Raman Scattering Micro-SpectroscopyThe Journal of Physical Chemistry Bhttps://doi.org/10.1021/acs.jpcb.8b07037
2018CARSNovakovic, Dunja and Isomäki, Antti and Pleunis, Bibi and Fraser-Miller, Sara J. and Peltonen, Leena and Laaksonen, Timo and Strachan, Clare J.Understanding Dissolution and Crystallization with Imaging: A Surface Point of ViewMol. Pharmaceuticshttps://doi.org/10.1021/acs.molpharmaceut.8b00840
2018SRSShi, Lingyan; Zheng, Chaogu; Shen, Yihui; Chen, Zhixing; Silveira, Edilson S.; Zhang, Luyuan; Wei, Mian; Liu, Chang; de Sena-Tomas, Carmen; Targoff, Kimara & Min, WeiOptical imaging of metabolic dynamics in animalsNature Communicationshttps://doi.org/10.1038/s41467-018-05401-3
2018CARSNiedieker, Daniel and GrosserÜschkamp, Frederik and Schreiner, Anja and Barkovits, Katalin and Kötting, Carsten and Marcus, Katrin and Gerwert, Klaus and Vorgerd, MatthiasLabel-free identification of myopathological features with coherent anti-Stokes Raman scatteringMuscle Nervehttps://doi.org/10.1002/mus.26140
2018CARSSmith, Matthew D.; Harley, Margaret E.; Kemp, Alain J.; Wills, Jimi; Lee, Martin; Arends, Mark; von Kriegsheim, Alex; Behrends, Christian & Wilkinson, SimonCCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER ProteostasisDevelopmental Cellhttps://doi.org/10.1016/j.devcel.2017.11.024
2018CARSSubramaniyam, Nagarajan; Shah, Ali; Dreser, Christoph; Isomaki, Antti; Fleischer, Monika & Sopanen, MarkkuNonlinear plasmonic behavior of nanohole arrays in thin gold films for imaging lipidsApplied Physics Lettershttps://doi.org/10.1063/1.5028118
2018SEHRSTrujillo, Michael J. & Camden, Jon P.Utilizing Molecular Hyperpolarizability for Trace Analysis: A Surface-Enhanced Hyper-Raman Scattering Study of Uranyl IonACS Omegahttps://doi.org/10.1021/acsomega.8b01147
2018SRSWei, Lu & Min, WeiElectronic Preresonance Stimulated Raman Scattering MicroscopyJ. Phys. Chem. Lett.https://doi.org/10.1021/acs.jpclett.8b00204
2018CARSXu, Binqian; Chen, Xiao Dong & Mercada-Prieto, RubenChemical imaging of protein hydrogels undergoing alkaline dissolution by CARS microscopyFood Chemistryhttps://doi.org/10.1016/j.foodchem.2018.01.056
2018quantum dotsZeuner, Katharina D.; Paul, Matthias; Lettner, Thomas; Reuterskiold Hedlund, Carl; Schweickert, Lucas; Steinhauer, Stephan; Yang, Lily; Zichi, Julien; Hammar, Mattias; Jons, Klaus D. & Zwiller, ValA stable wavelength-tunable triggered source of single photons and cascaded photon pairs at the telecom C-bandApplied Physics Lettershttps://doi.org/10.1063/1.5021483
2017CARSAdamiak, Justyna; Bonifay, Vincent; Otlewska, Anna; Sunner, Jan A.; Beech, Iwona B.; Stryszewska, Teresa; Kanka, Stanislaw; Oracz, Joanna; Zyzelewicz, Dorota & Gutarowska, BeataUntargeted Metabolomics Approach in Halophiles: Understanding the Biodeterioration Process of Building MaterialsFrontiers in Microbiologyhttps://doi.org/10.3389/fmicb.2017.02448
2017CARSBille, Josef F.; Engelhardt, Johann; Volpp, Hans-Robert; Laghouissa, Abdelmoutalib; Motzkus, Marcus; Jiang, Zhongxiang & Sahler, RuthChemical basis for alteration of an intraocular lens using a femtosecond laserBiomed. Opt. Expresshttps://doi.org/10.1364/BOE.8.001390
2017CARSCavalheiro, R.P.; Lima, M.A.; Jarrouge-Boucas, T.R.; Viana, G.M.; Lopes, C.C.; Coulson-Thomas, V.J.; Dreyfuss, J.L.; Yates, E.A.; Tersariol, I.L.S. & Nader, H.B.Coupling of vinculin to F-actin demands Syndecan-4 proteoglycanMatrix Biologyhttps://doi.org/10.1016/j.matbio.2016.12.006
2017CARSHarvald, Eva Bang; Sprenger, Richard R.; Dall, Kathrine Brandgaard; Ejsing, Christer S.; Nielsen, Ronni; Mandrup, Susanne; Murillo, Alejandro Brenes; Larance, Mark; Gartner, Anton; Lamond, Angus I. & Faergeman, Nils J.Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegansCell Systemshttps://doi.org/10.1016/j.cels.2017.06.004
2017SRSKlossek, A.; Thierbach, S.; Rancan, F.; Vogt, A.; Blume-Peytavi, U. & Ruhl, E.Studies for improved understanding of lipid distributions in human skin by combining stimulated and spontaneous Raman microscopyEuropean Journal of Pharmaceutics and Biopharmaceuticshttps://doi.org/10.1016/j.ejpb.2016.11.001
2017CARSLafeta¡, Lucas; Cadore, Alisson R.; Mendes-de-Sa, Thiago G.; Watanabe, Kenji; Taniguchi, Takashi; Campos, Leonardo C.; Jorio, Ado & Malard, Leandro M.Anomalous Nonlinear Optical Response of Graphene Near Phonon ResonancesNano Lettershttps://doi.org/10.1021/acs.nanolett.7b00329
2017SRSLi, Xuesong; Jiang, Meijuan; Lam, Jacky W. Y.; Tang, Ben Zhong & Qu, Jianan Y.Mitochondrial Imaging with Combined Fluorescence and Stimulated Raman Scattering Microscopy Using a Probe of the Aggregation-Induced Emission CharacteristicJournal of the American Chemical Societyhttps://doi.org/10.1021/jacs.7b06273
2017SRSLombardini, Alberto; Andresen, Esben Ravn; Kudlinski, Alexandre; Rimke, Ingo & Rigneault, HervèOrigin and suppression of parasitic signals in Kagomé lattice hollow core fibers used for SRS microscopy and endoscopyOpt. Lett.https://doi.org/10.1364/OL.42.001824
2017SFGMah, Pei; Novakovic, Dunja; Saarinen, Jukka; Landeghem, Stijn; Peltonen, Leena; Laaksonen, Timo; Isomaki, Antti & Strachan, ClareElucidation of Compression-Induced Surface Crystallization in Amorphous Tablets Using Sum Frequency Generation (SFG) MicroscopyPharmaceutical Researchhttps://doi.org/10.1007/s11095-016-2046-6
2017TPEFMercada-Prieto, Ruben; Rodriguez-Rivera, Luis & Chen, Xiao DongFluorescence lifetime of Rhodamine B in aqueous solutions of polysaccharides and proteins as a function of viscosity and temperaturePhotochem. Photobiol. Sci.https://doi.org/10.1039/C7PP00330G
2017SRS, CARSStiebing, Clara; Meyer, Tobias; Rimke, Ingo; Mattheus, Christian; Schmitt, Michael; Lorkowski, Stefan & Popp, JurgenReal-time Raman and SRS imaging of living human macrophages reveals cell-to-cell heterogeneity and dynamics of lipid uptakeJournal of Biophotonicshttps://doi.org/10.1002/jbio.201600279
2017SRSTipping, William J.; Lee, Martin; Serrels, Alan; Brunton, Valerie G. & Hulme, Alison N.Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopyChem. Sci.https://doi.org/10.1039/C7SC01837A
2017SRSWei, Lu; Chen, Zhixing; Shi, Lixue; Long, Rong; Anzalone, Andrew V.; Zhang, Luyuan; Hu, Fanghao; Yuste, Rafael; Cornish, Virginia W. & Min, WeiSuper-multiplex vibrational imagingNaturehttps://doi.org/10.1038/nature22051
2017CARS, SHGYosef, Hesham K.; Krauss, Sascha D.; Lechtonen, Tatjana; Jùtte, Hendrik; Tannapfel, Andrea; Käfferlein, Heiko U.; Bräning, Thomas; Roghmann, Florian; Noldus, Joachim; Mosig, Axel; El-Mashtoly, Samir F. & Gerwert, KlausNoninvasive Diagnosis of High-Grade Urothelial Carcinoma in Urine by Raman Spectral ImagingAnalytical Chemistryhttps://doi.org/10.1021/acs.analchem.7b01403
2017CARSPetersen, D. and Mavarani, L. and Niedieker, D. and Freier, E. and Tannapfel, A. and Kötting, C. and Gerwert, K. and El-Mashtoly, S. F.Virtual staining of colon cancer tissue by label-free Raman micro-spectroscopyAnalysthttps://doi.org/10.1039/C6AN02072K
2017CARSSaarinen, Jukka and Sözeri, Erkan and Fraser-Miller, Sara J. and Peltonen, Leena and Santos, Hélder A. and Isomäki, Antti and Strachan, Clare J.Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopyInternational Journal of Pharmaceuticshttps://doi.org/10.1016/j.ijpharm.2017.03.015
2017CARSPfisterer, Simon G. and Gateva, Gergana and Horvath, Peter and Pirhonen, Juho and Salo, Veijo T. and Karhinen, Leena and Varjosalo, Markku and Ryhänen, Samppa J. and Lappalainen, Pekka and Ikonen, ElinaRole for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storageNature Communicationshttps://doi.org/10.1038/ncomms14858
2017SRSYu, Yong; Mutlu, Ayse Sena; Liu, Harrison & Wang, Meng C.High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidationNature Communicationshttps://doi.org/10.1038/s41467-017-00944-3
2017SRSZhang, Luyuan & Min, WeiBioorthogonal chemical imaging of metabolic changes during epithelial–mesenchymal transition of cancer cells by stimulated Raman scattering microscopy.Journal of Biomedical Opticshttps://doi.org/10.1117/1.JBO.22.10.106010
2016CARSCaine, Sally; Hackett, Mark J.; Hou, Huishu; Kumar, Saroj; Maley, Jason; Ivanishvili, Zurab; Suen, Brandon; Szmigielski, Aleksander; Jiang, Zhongxiang; Sylvain, Nicole J.; Nichol, Helen & Kelly, Michael E.A novel multi-modal platform to image molecular and elemental alterations in ischemic strokeNeurobiology of Diseasehttps://doi.org/10.1016/j.nbd.2016.03.006
2016SRSGiulbudagian, Michael; Rancan, Fiorenza; Klossek, Andre; Yamamoto, Kenji; Jurisch, Jana; Neto, Victor Colombo; Schrade, Petra; Bachmann, Sebastian; Ruhl, Eckart; Blume-Peytavi, Ulrike; Vogt, Annika & Calderan, MarceloCorrelation between the chemical composition of thermoresponsive nanogels and their interaction with the skin barrierJournal of Controlled Releasehttps://doi.org/10.1016/j.jconrel.2016.10.022
2016SRSHu, Fanghao; Lamprecht, Michael R.; Wei, Lu; Morrison, Barclay & Min, WeiBioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scatteringScientific Reportshttps://doi.org/10.1038/srep39660
2016SRSLu, Fake; Calligaris, David; Olubiyi, Olutayo; Norton, Isaiah; Yang, Wenlong; Santagata, Sandro; Xie, X; Golby, Alexandra & Agar, NathalieLabel-Free Neurosurgical Pathology with Stimulated Raman ImagingCancer Researchhttps://doi.org/10.1158/0008-5472.CAN-16-0270
2016SHG, TPEFMendive-Tapia, Lorena; Zhao, Can; Akram, Ahsan R.; Preciado, Sara; Albericio, Fernando; Lee, Martin; Serrels, Alan; Kielland, Nicola; Read, Nick D.; Lavilla, Rodolfo & Vendrell, MarcSpacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissueNature Communicationshttps://doi.org/10.1038/ncomms10940
2016CARS, SHGPirhonen, Juho; Arola, Johanna; Sadevirta Sanja; Luukkonen Panu; Karppinen Sanna-Maria; Pihlajaniemi Taina; Isomaki Antti; Hukkanen Mika; Yki-Jarvinen Hannele; Ikonen ElinaContinuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept StudyPLOS ONEhttps://doi.org/10.1371/journal.pone.0147804
2016SRSTian, Feng; Yang, Wenlong; Mordes, Daniel A.; Wang, Jin-Yuan; Salameh, Johnny S.; Mok, Joanie; Chew, Jeannie; Sharma, Aarti; Leno-Duran, Ester; Suzuki-Uematsu, Satomi; Suzuki, Naoki; Han, Steve S.; Lu, Fa-Ke; Ji, Minbiao; Zhang, Rosanna; Liu, Yue; Strominger, Jack; Shneider, Neil A.; Petrucelli, Leonard; Xie, X. Sunney & Eggan, KevinMonitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imagingNature Communicationshttps://doi.org/10.1038/ncomms13283
2016CARSThorsted, Bjarne and Bloksgaard, Maria and Groza, Alexandra and Schousboe, Lars Peter and Færgeman, Nils J. and Sørensen, Jens A. and Svane-Knudsen, Viggo and Brewer, Jonathan R.Biochemical and Bioimaging Evidence of Cholesterol in Acquired CholesteatomaAnn Otol Rhinol Laryngolhttps://doi.org/10.1177/0003489416642784
2016CARSWaschatko, Gustav and Billecke, Nils and Schwendy, Sascha and Jaurich, Henriette and Bonn, Mischa and Vilgis, Thomas A. and Parekh, Sapun H.Label-free in situ imaging of oil body dynamics and chemistry in germinationJournal of The Royal Society Interfacehttps://doi.org/10.1098/rsif.2016.0677
2016SEHRSTurley, Hubert K.; Hu, Zhongwei; Silverstein, Daniel W.; Cooper, David A.; Jensen, Lasse & Camden, Jon P.Probing Two-Photon Molecular Properties with Surface-Enhanced Hyper-Raman Scattering: A Combined Experimental and Theoretical Study of Crystal VioletThe Journal of Physical Chemistry Chttps://doi.org/10.1021/acs.jpcc.6b02746
2015CARSChristophersen, Philip C.; Birch, Ditlev; Saarinen, Jukka; Isomaki, Antti; Nielsen, Hanne M.; Yang, Mingshi; Strachan, Clare J. & Mu, HuilingInvestigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopyJournal of Controlled Releasehttps://doi.org/10.1016/j.jconrel.2014.10.023
2015SRS, TPEFNa, Huimin; Zhang, Peng; Chen, Yong; Zhu, Xiaotong; Liu, Yi; Liu, Yangli; Xie, Kang; Xu, Ningyi; Yang, Fuquan; Yu, Yong; Cichello, Simon; Mak, Ho Yi; Wang, Meng C.; Zhang, Hong & Liu, PingshengIdentification of lipid droplet structure-like/resident proteins in Caenorhabditis elegansBiochimica et Biophysica Acta (BBA) - Molecular Cell Researchhttps://doi.org/10.1016/j.bbamcr.2015.05.020
2015CARS, SHGDarville, Nicolas; Saarinen, Jukka; Isomaki, Antti; Khriachtchev, Leonid; Cleeren, Dirk; Sterkens, Patrick; van Heerden, Marjolein; Annaert, Pieter; Peltonen, Leena; Santos, Helder A.; Strachan, Clare J. & den Mooter, Guy VanMultimodal non-linear optical imaging for the investigation of drug nano-/microcrystal cell interactionsEuropean Journal of Pharmaceutics and Biopharmaceuticshttps://doi.org/10.1016/j.ejpb.2015.09.003
2015SRSLu, Fa-Ke; Basu, Srinjan; Igras, Vivien; Hoang, Mai P.; Ji, Minbiao; Fu, Dan; Holtom, Gary R.; Neel, Victor A.; Freudiger, Christian W.; Fisher, David E. & Xie, X. SunneyLabel-free DNA imaging in vivo with stimulated Raman scattering microscopyProceedings of the National Academy of Scienceshttps://doi.org/10.1073/pnas.1515121112
2015SRSRamachandran, Prasanna V.; Mutlu, Ayse Sena & Wang, Meng C.Label-Free Biomedical Imaging of Lipids by Stimulated Raman Scattering MicroscopyCurrent Protocols in Molecular Biologyhttps://doi.org/10.1002/0471142727.mb3003s109
2015SEHRSSimmons, Philip D.; Turley, Hubert K.; Silverstein, Daniel W.; Jensen, Lasse & Camden, Jon P.Surface-Enhanced Spectroscopy for Higher-Order Light Scattering: A Combined Experimental and Theoretical Study of Second Hyper-Raman ScatteringThe Journal of Physical Chemistry Lettershttps://doi.org/10.1021/acs.jpclett.5b02342
2015SHGGerhard Sommer and Andreas J. Schriefl and Michaela Andrä and Michael Sacherer and Christian Viertler and Heimo Wolinski and Gerhard A. HolzapfelBiomechanical properties and microstructure of human ventricular myocardium Acta Biomaterialia https://doi.org/10.1016/j.actbio.2015.06.031
2015CARSYang, Chen and Niedieker, Daniel and Großerüschkamp, Frederik and Horn, Melanie and Tannapfel, Andrea and Kallenbach-Thieltges, Angela and Gerwert, Klaus and Mosig, AxelFully automated registration of vibrational microspectroscopic images in histologically stained tissue sectionsBMC Bioinformaticshttps://doi.org/10.1186/s12859-015-0804-9
2015CARSAstanina, Ksenia and Koch, Marcus and Jüngst, Christian and Zumbusch, Andreas and Kiemer, Alexandra K.Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cellsScientific Reportshttps://doi.org/10.1038/srep11453
2015CARSTaschler, Ulrike; Schreiber, Renate; Chitraju, Chandramohan; Grabner, Gernot F.; Romauch, Matthias; Wolinski, Heimo; Haemmerle, Guenter; Breinbauer, Rolf; Zechner, Rudolf; Lass, Achim & Zimmermann, RobertAdipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cellsBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipidshttps://doi.org/10.1016/j.bbalip.2015.02.017
2015CARSWolinski, Heimo; Hofbauer, Harald; Cristobal-Sarramian, Alvaro; Kolb-Lenz, Dagmar; Radulovic, Maja; Knittelfelder, Oskar; Rechberger, Gerald & Kohlwein, SeppSeipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeastBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipidshttps://doi.org/10.1016/j.bbalip.2015.08.003
2015CARSWolinski, Heimo & Kohlwein, SeppMicroscopic and Spectroscopic Techniques to Investigate Lipid Droplet Formation and Turnover in YeastMethods in molecular biology (Clifton, N.J.)https://doi.org/10.1007/978-1-4939-2309-0_21
2014CARSBarros, Alexandre Guimaraes de Almeida; Bridi, Jessika Cristina; de Souza Bruno Rezende; de Castro Junior Celio; de Lima Torres Karen Cecilia; Malard Leandro; Jorio Ado; de Miranda Debora Marques; Ashrafi Kaveh; Romano-Silva Marco AurelioDopamine Signaling Regulates Fat Content through B-Oxidation in Caenorhabditis elegansPLOS ONEhttps://doi.org/10.1371/journal.pone.0085874
2014CARS, TPEFChau, You-Ying; Bandiera, Roberto; Serrels, Alan; Mart'inez-Estrada, Ofelia M; Qing, Wei; Lee, Martin; Slight, Joan; Thornburn, Anna; Berry, Rachel; Mchaffie, Sophie; Stimson, Roland H; Walker, Brian R; Chapuli, Ramon Munoz; Schedl, Andreas & Hastie, NickVisceral and subcutaneous fat have different origins and evidence supports a mesothelial source.Nature Cell Biologyhttps://doi.org/10.1038/ncb2922
2014-Chen, Tao; Chen, Shouhui; Zhou, Jihan; Liang, Dehai; Chen, Xiaoyuan & Huang, YanyiTransient absorption microscopy of gold nanorods as spectrally orthogonal labels in live cellsNanoscalehttps://doi.org/10.1039/C4NR03413A
2014SRSChen, Zhixing; Paley, Daniel W.; Wei, Lu; Weisman, Andrew L.; Friesner, Richard A.; Nuckolls, Colin & Min, WeiMulticolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational PaletteJournal of the American Chemical Societyhttps://doi.org/10.1021/ja502706q
2014CARSCunningham, Katherine A.; Bouagnon, Aude D.; Barros Alexandre G.;Lin Lin; Malard Leandro; Romano-Silva Marco Aurelio; Ashrafi KavehLoss of a Neural AMP-Activated Kinase Mimics the Effects of Elevated Serotonin on Fat, Movement, and Hormonal SecretionsPLOS Geneticshttps://doi.org/10.1371/journal.pgen.1004394
2014CARSEl-Mashtoly, Samir F.; Niedieker, Daniel; Petersen, Dennis; Krauss, Sascha D.; Freier, Erik; Maghnouj, Abdelouahid; Mosig, Axel; Hahn, Stephan; Kotting, Carsten & Gerwert, KlausAutomated identification of subcellular organelles by coherent anti-stokes Raman scatteringBiophysical journalhttps://doi.org/10.1016/j.bpj.2014.03.025
2014SRSFu, Dan; Yu, Yong; Folick, Andrew; Currie, Erin; Robert V. Farese, Jr.; Tsai, Tsung-Huang; Xie, Xiaoliang Sunney & Wang, Meng C.In Vivo Metabolic Fingerprinting of Neutral Lipids with Hyperspectral Stimulated Raman Scattering MicroscopyJournal of the American Chemical Societyhttps://doi.org/10.1021/ja504199s
2014CARSJeschke, Steffen; Mutke, Monika; Jiang, Zhongxiang; Alt, Burkhard & Wiemhofer, Hans-DieterStudy of Carbamate-Modified Disiloxane in Porous PVDF-HFP Membranes: New Electrolytes/Separators for Lithium-Ion BatteriesChemPhysChemhttps://doi.org/10.1002/cphc.201400065
2014CARS, SHGPark, Joo Hyun; Lee, Eun-Soo; Lee, Jae Yong; Lee, Eun Seong; Lee, Tae Geol; Kim, Se-Hwa & Lee, Sang-WonMultimodal Nonlinear Optical Microscopy for Simultaneous 3-D Label-Free and Immunofluorescence Imaging of Biological SamplesJ. Opt. Soc. Koreahttps://doi.org/10.3807/JOSK.2014.18.5.551
2014CARS, SRSWei, Lu; Hu, Fanghao; Shen, Yihui; Chen, Zhixing; Yu, Yong; Lin, Chih-Chun; Wang, Meng C & Min, WeiLive-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scatteringNature methodshttps://doi.org/10.1038/nmeth.2878
20142PLWi, Jung-Sub; Park, Joo Hyun; Tominaka, Satoshi & Lee, Jae YongEnhanced two-photon luminescence from nanoporous gold capped with microcontact-printed saltsphysica status solidi (RRL) – Rapid Research Lettershttps://doi.org/10.1002/pssr.201308208
2014CARSvan Zutphen, Tim; Todde, Virginia; de Boer, Rinse; Kreim, Martin; Hofbauer, Harald F.; Wolinski, Heimo; Veenhuis, Marten; van der Klei, Ida J. & Kohlwein, Sepp D.Lipid droplet autophagy in the yeast Saccharomyces cerevisiaeMolecular Biology of the Cellhttps://doi.org/10.1091/mbc.e13-08-0448
2013SHGSchriefl, Andreas Jorg; Wolinski, Heimo; Kohlwein, Sepp D. & Holzapfel, GerhardStructural Differences in Collagen Morphologies between Healthy and AAA TissuesThe 4th Canadian Conference on Nonlinear Solid Mechanicshttps://doi.org/10.1098/rsif.2012.0760
2013CARSRadulovic, Maja and Knittelfelder, Oskar and Cristobal-Sarramian, Alvaro and Kolb, Dagmar and Wolinski, Heimo and Kohlwein, Sepp D.The emergence of lipid droplets in yeast: current status and experimental approachesCurrent Geneticshttps://doi.org/10.1007/s00294-013-0407-9
2013SHGSchriefl, Andreas J.; Wolinski, Heimo; Regitnig, Peter; Kohlwein, Sepp D. & Holzapfel, Gerhard A.An automated approach for three-dimensional quantification of fibrillar structures in optically cleared soft biological tissuesJournal of The Royal Society Interfacehttps://doi.org/10.1098/rsif.2012.0760
2013SRSWei, Lu; Yu, Yong; Shen, Yihui; Wang, Meng C & Min, WeiVibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopyProceedings of the National Academy of Sciences of the United States of Americahttps://doi.org/10.1073/pnas.1303768110
2012SRSIto, Terumasa; Ji, Minbiao; Holtom, Gary & Xie, X. SunneyEpi-Detected Stimulated Raman Scattering Microscopy Using Long-Wavelength ExcitationBiomedical Optics and 3-D Imaginghttps://doi.org/10.1364/BIOMED.2012.BSu4B.7
2012CARSPaar, Margret; Jungst, Christian; Steiner, Noemi A.; Magnes, Christoph; Sinner, Frank; Kolb, Dagmar; Lass, Achim; Zimmermann, Robert; Zumbusch, Andreas; Kohlwein, Sepp D. & Wolinski, HeimoRemodeling of lipid droplets during lipolysis and growth in adipocytesThe Journal of biological chemistryhttps://doi.org/10.1074/jbc.M111.316794
2012SHGSchriefl, Andreas J.; Reinisch, Andreas J.; Sankaran, Sethuraman; Pierce, David M. & Holzapfel, Gerhard A.Quantitative assessment of collagen fibre orientations from two-dimensional images of soft biological tissuesJournal of The Royal Society Interfacehttps://doi.org/10.1098/rsif.2012.0339
2014CARSAntti Isomäki, Tarvo Sillat, Mari Ainola, Mikko Liljeström, Yrjö T. Konttinen, Mika HukkanenLabel-Free Imaging of Adipogenesis by Coherent Anti-Stokes Raman Scattering MicroscopyBook - Arthritis Research: Methods and Protocolshttps://doi.org/10.1007/978-1-4939-0404-4_16
2013SHGSchriefl, Andreas JorgQuantification of Collagen Fiber Morphologies in Human Arterial Walls: Novel Experimental Methodologies yielding 2D and 3D Structural DataBook - Monographic Series TU Graz: Computation in Engineering and Sciencehttps://doi.org/10.3217/978-3-85125-238-5
2012CARSWolinski, Heimo; Bredies, Kristian & Kohlwein, Sepp D.Chapter 16 - Quantitative Imaging of Lipid Metabolism in Yeast: From 4D Analysis to High Content Screens of Mutant LibrariesBook - Methods in Cell Biologyhttps://doi.org/10.1016/B978-0-12-386487-1.00016-X

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Phone: +81 48 871 0067
Email: voc@phototechnica.co.jp
Website: www.phototechnica.co.jp

RayVis
Seoul 137-862, Korea

Phone: +82 2 3461 1103
Email: sales@rayvis.co.kr
Website: www.rayvis.co.kr

STARK SCIENTIFIC S.A. DE C.V.
Guty Cardenas 147, Guadalupe Inn
Ciudad de Mexico, C.P. 01020, Mexico

Main Contact: Vicente Garcia Gomez

Phone: +52 555 401 8254
Email: sales@starkscientific.com

Eurotek International
02-668 Warsaw, Poland

Phone: +48 22 843 79 40
Email: eurotek@eurotek.com.pl
Website: www.eurotek.com

Innova Scientific S.L.
28290 Las Rozas de Madrid, Espana

Phone: +34 91 7105650
Email: info@innovasci.com
Website: www.innovasci.com

AceXon Technologies Pte. Ltd.
Singapore 658065

Phone: +65 6565 7300
Email: sales@acexon.com
Website: www.acexontech.com

Innova Scientific S.L.
28290 Las Rozas de Madrid
Espana

Phone: +34 91 7105650
Email: info@innovasci.com
Website: www.innovasci.com

APE Angewandte Physik & Elektronik GmbH
Plauener Strasse 163-165 | Haus N
13053 Berlin, Germany

Phone: +49 30 986 011-30
Fax: +49 30 986011333

Sales: sales@ape-berlin.de
Support: service@ape-berlin.de

SuperbIN Company Ltd.
5F., No. 41, Ln. 15, Sec. 6, Minquan E. Rd., Taipei 114
Taiwan, R.O.C.

Phone: +886-2-2793-0866
Fax: +886-2-2793-0855
Email: info@superbin.com.tw
Website: www.superbin.com.tw

APE Applied Physics & Electronics, Inc.
Vancouver | WA | USA

Phone: +1 888 690 3250
Sales: sales@ape-america.com
Support: service@ape-america.com